Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3821167..3821786 Replicon chromosome
Accession NZ_CP090222
Organism Klebsiella pneumoniae strain BY11

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LVJ01_RS18810 Protein ID WP_002892050.1
Coordinates 3821568..3821786 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LVJ01_RS18805 Protein ID WP_002892066.1
Coordinates 3821167..3821541 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ01_RS18795 (3816319) 3816319..3817512 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LVJ01_RS18800 (3817535) 3817535..3820681 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LVJ01_RS18805 (3821167) 3821167..3821541 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LVJ01_RS18810 (3821568) 3821568..3821786 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LVJ01_RS18815 (3821945) 3821945..3822511 + 567 WP_002892030.1 maltose O-acetyltransferase -
LVJ01_RS18820 (3822483) 3822483..3822623 - 141 WP_004147370.1 hypothetical protein -
LVJ01_RS18825 (3822644) 3822644..3823114 + 471 WP_002892026.1 YlaC family protein -
LVJ01_RS18830 (3823089) 3823089..3824540 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LVJ01_RS18835 (3824641) 3824641..3825339 + 699 WP_004178762.1 GNAT family protein -
LVJ01_RS18840 (3825336) 3825336..3825476 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LVJ01_RS18845 (3825476) 3825476..3825739 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T230316 WP_002892050.1 NZ_CP090222:3821568-3821786 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T230316 NZ_CP124839:32475-32771 [Klebsiella pneumoniae]
ATGATAGAAATAAAACGGACGCCGGAAGTTGAAAAGTGGCTCAGGTCTTTGAAGGACAGAACGGCAAAGGCAAAAATATT
GATGCGACTTGAGCGCATGGAGGACGGAAATTTTGGAGACGTGGAGCCAATAGGTGACGGATTATCAGAATTAAGGATTC
ATCAGGGTAAAGGCTACCGTGTGTATTTTGGAAACAAAAACAATCAAATTATTCTCTTGCTTTGTGGTGGAGATAAAAGC
ACGCAGCAAGCAGATATCAGAAAAGCGAAACAATTAGCTAAACAGTGGGGGTTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT230316 WP_002892066.1 NZ_CP090222:3821167-3821541 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT230316 NZ_CP124839:32773-33057 [Klebsiella pneumoniae]
ATGAAAGAAGAACTTAAAAAATTTGATGTTGTTGAATTTCTTGAAGATGAAGAAGATATTCAGGAATATCTTAATGCGGC
AATTGAAGAAGATGATACAAAATATCTTTTTAAAGCATTAGGTAACATAGCCAGAGCAAGAAACATAAGTCAGCTATCTA
AAGAAGTTGGTATGTCCAGGGAGGGAATTTACAAGGCGTTATCCGGTGAAGGAAATCCATCATTCCAGACTGTCTCTAAA
ATCACAAAAGCACTTGGTTTAAAACTTCACTTCACAGGGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References