Detailed information of TA system TA230314

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2446772..2448360
• Replicon: chromosome
• Accession: NZ_CP090222
• Organism: Klebsiella pneumoniae strain BY11

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LVJ01_RS12200
• Protein ID: WP_004179815.1
• Coordinates: 2446772..2448094 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LVJ01_RS12205
• Protein ID: WP_004176198.1
• Coordinates: 2448094..2448360 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LVJ01_RS12185 (2441828)	2441828..2444329	+	2502	WP_004179823.1	fimbria/pilus outer membrane usher protein	-
LVJ01_RS12190 (2444317)	2444317..2445321	+	1005	WP_004179822.1	fimbrial protein	-
LVJ01_RS12195 (2445463)	2445463..2446755	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
LVJ01_RS12200 (2446772)	2446772..2448094	-	1323	WP_004179815.1	type II toxin-antitoxin system HipA family toxin	Toxin
LVJ01_RS12205 (2448094)	2448094..2448360	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LVJ01_RS12210 (2448626)	2448626..2448952	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
LVJ01_RS12215 (2448949)	2448949..2449449	-	501	WP_004179811.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LVJ01_RS12220 (2449427)	2449427..2450806	-	1380	WP_004179808.1	nucleobase:cation symporter-2 family protein	-
LVJ01_RS12225 (2451152)	2451152..2452306	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
LVJ01_RS12230 (2452287)	2452287..2453210	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T230314 WP_004179815.1 NZ_CP090222:c2448094-2446772 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T230314 NZ_CP124838:c56307-55891 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT230314 WP_004176198.1 NZ_CP090222:c2448360-2448094 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT230314 NZ_CP124838:c56534-56304 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA