Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5119324..5119949 Replicon chromosome
Accession NZ_CP090218
Organism Klebsiella pneumoniae strain BY221

Toxin (Protein)


Gene name vapC Uniprot ID A0A378FVD4
Locus tag LVJ43_RS25035 Protein ID WP_019705794.1
Coordinates 5119324..5119707 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag LVJ43_RS25040 Protein ID WP_004150355.1
Coordinates 5119707..5119949 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ43_RS25020 (5116690) 5116690..5117592 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
LVJ43_RS25025 (5117589) 5117589..5118224 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
LVJ43_RS25030 (5118221) 5118221..5119150 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
LVJ43_RS25035 (5119324) 5119324..5119707 - 384 WP_019705794.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ43_RS25040 (5119707) 5119707..5119949 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
LVJ43_RS25045 (5120154) 5120154..5121071 + 918 WP_004146235.1 alpha/beta hydrolase -
LVJ43_RS25050 (5121086) 5121086..5122027 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
LVJ43_RS25055 (5122072) 5122072..5122509 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
LVJ43_RS25060 (5122506) 5122506..5123366 - 861 WP_004146232.1 virulence factor BrkB family protein -
LVJ43_RS25065 (5123360) 5123360..5123959 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14358.57 Da        Isoelectric Point: 6.8806

>T230297 WP_019705794.1 NZ_CP090218:c5119707-5119324 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGHREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T230297 NZ_CP124827:c4510361-4509828 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT230297 WP_004150355.1 NZ_CP090218:c5119949-5119707 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT230297 NZ_CP124827:c4510638-4510372 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378FVD4

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References