Detailed information of TA system TA230296

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4777185..4778866
• Replicon: chromosome
• Accession: NZ_CP090218
• Organism: Klebsiella pneumoniae strain BY221

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A483YLF8
• Locus tag: LVJ43_RS23480
• Protein ID: WP_019724882.1
• Coordinates: 4777185..4778102 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: LVJ43_RS23485
• Protein ID: WP_004177809.1
• Coordinates: 4778108..4778866 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LVJ43_RS23460 (4772491)	4772491..4774011	+	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-
LVJ43_RS23465 (4774008)	4774008..4775006	+	999	WP_002885172.1	ribose ABC transporter permease	-
LVJ43_RS23470 (4775037)	4775037..4775978	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
LVJ43_RS23475 (4776053)	4776053..4777060	+	1008	WP_064152101.1	carbohydrate kinase family protein	-
LVJ43_RS23480 (4777185)	4777185..4778102	-	918	WP_019724882.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LVJ43_RS23485 (4778108)	4778108..4778866	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
LVJ43_RS23490 (4778952)	4778952..4779680	-	729	WP_002885152.1	response regulator transcription factor	-
LVJ43_RS23495 (4779953)	4779953..4782100	+	2148	WP_077625403.1	formate dehydrogenase subunit alpha	-
LVJ43_RS23500 (4782330)	4782330..4783016	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34653.14 Da
• Isoelectric Point: 5.4707

>T230296 WP_019724882.1 NZ_CP090218:c4778102-4777185 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CITQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T230296 NZ_CP124827:3895876-3896094 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT230296 WP_004177809.1 NZ_CP090218:c4778866-4778108 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT230296 NZ_CP124827:3895475-3895849 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Toxin

• AlphaFold DB: A0A483YLF8

Antitoxin

• AlphaFold DB: A6TH05