Detailed information of TA system TA230277

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 823002..824724
• Replicon: chromosome
• Accession: NZ_CP090217
• Organism: Providencia rettgeri strain YK205

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: D0FZT9
• Locus tag: LVJ10_RS03645
• Protein ID: WP_000356587.1
• Coordinates: 823786..824724 (+)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: LVJ10_RS03640
• Protein ID: WP_048608544.1
• Coordinates: 823002..823793 (+)
• Length: 264 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LVJ10_RS03610 (LVJ10_03600)	818675..818956	+	282	WP_000433889.1	type IV conjugative transfer system protein TraL	-
LVJ10_RS03615 (LVJ10_03605)	818953..819579	+	627	WP_000667170.1	TraE/TraK family type IV conjugative transfer system protein	-
LVJ10_RS03620 (LVJ10_03610)	819563..820459	+	897	WP_048608549.1	type-F conjugative transfer system secretin TraK	-
LVJ10_RS03625 (LVJ10_03615)	820462..821751	+	1290	WP_085285719.1	TraB/VirB10 family protein	-
LVJ10_RS21190	822177..822398	+	222	WP_282551145.1	TraV family lipoprotein	-
LVJ10_RS03635 (LVJ10_03625)	822395..822781	+	387	WP_048608546.1	TraA family conjugative transfer protein	-
LVJ10_RS03640 (LVJ10_03630)	823002..823793	+	792	WP_048608544.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
LVJ10_RS03645 (LVJ10_03635)	823786..824724	+	939	WP_000356587.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LVJ10_RS03650 (LVJ10_03640)	824856..825548	+	693	WP_001228924.1	DsbC family protein	-
LVJ10_RS03655 (LVJ10_03645)	825548..827947	+	2400	WP_048608542.1	type IV secretion system protein TraC	-
LVJ10_RS03660 (LVJ10_03650)	827940..828287	+	348	WP_048608540.1	hypothetical protein	-
LVJ10_RS03665 (LVJ10_03655)	828271..828783	+	513	WP_172689549.1	S26 family signal peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	ARR-3 / dfrA27 / aadA16 / qacE / sul1 / blaPER-1 / aph(3')-VIb / tet(C) / aadA6 / mph(A)	-	692162..898517	206355

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-97)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35548.82 Da
• Isoelectric Point: 4.9081

>T230277 WP_000356587.1 NZ_CP090217:823786-824724 [Providencia rettgeri]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Nucleotide

• Length: 939 bp

>T230277 NZ_CP124824:815164-815574 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 264 a.a.
• Molecular weight: 30100.44 Da
• Isoelectric Point: 9.3513

>AT230277 WP_048608544.1 NZ_CP090217:823002-823793 [Providencia rettgeri]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPDAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Nucleotide

• Length: 792 bp

>AT230277 NZ_CP124824:814917-815183 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A1U9VZ44