Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 10117..10639 | Replicon | plasmid pBY68-3 |
| Accession | NZ_CP090215 | ||
| Organism | Escherichia coli strain BY68 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G3CAN5 |
| Locus tag | LVJ26_RS24490 | Protein ID | WP_000220560.1 |
| Coordinates | 10358..10639 (+) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G3CAG1 |
| Locus tag | LVJ26_RS24485 | Protein ID | WP_000121743.1 |
| Coordinates | 10117..10368 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ26_RS24455 (LVJ26_24375) | 5480..5710 | + | 231 | WP_000051064.1 | plasmid partition protein ParG | - |
| LVJ26_RS24460 (LVJ26_24380) | 5726..6019 | + | 294 | WP_015060510.1 | hypothetical protein | - |
| LVJ26_RS24465 (LVJ26_24385) | 6021..6989 | + | 969 | WP_077783213.1 | IS5-like element IS903B family transposase | - |
| LVJ26_RS24470 (LVJ26_24390) | 7049..7402 | - | 354 | WP_000876434.1 | DNA distortion polypeptide 3 | - |
| LVJ26_RS24475 (LVJ26_24395) | 7539..7985 | - | 447 | WP_001074386.1 | hypothetical protein | - |
| LVJ26_RS24480 (LVJ26_24400) | 8025..8861 | - | 837 | WP_001050931.1 | RepB family plasmid replication initiator protein | - |
| LVJ26_RS24485 (LVJ26_24405) | 10117..10368 | + | 252 | WP_000121743.1 | plasmid stabilization protein | Antitoxin |
| LVJ26_RS24490 (LVJ26_24410) | 10358..10639 | + | 282 | WP_000220560.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LVJ26_RS24495 (LVJ26_24415) | 10785..11108 | + | 324 | WP_001181903.1 | hypothetical protein | - |
| LVJ26_RS24500 (LVJ26_24420) | 11153..11398 | + | 246 | WP_000356546.1 | hypothetical protein | - |
| LVJ26_RS24505 (LVJ26_24425) | 11388..11603 | + | 216 | WP_001180116.1 | hypothetical protein | - |
| LVJ26_RS24510 (LVJ26_24430) | 11696..12025 | + | 330 | WP_000866648.1 | hypothetical protein | - |
| LVJ26_RS24515 (LVJ26_24435) | 12312..12461 | + | 150 | WP_000003880.1 | hypothetical protein | - |
| LVJ26_RS24520 (LVJ26_24440) | 12474..12746 | + | 273 | WP_000160399.1 | hypothetical protein | - |
| LVJ26_RS24525 (LVJ26_24445) | 13072..13617 | + | 546 | WP_015060502.1 | DNA distortion polypeptide 1 | - |
| LVJ26_RS24530 (LVJ26_24450) | 13620..14786 | + | 1167 | WP_000539530.1 | MobP1 family relaxase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaTEM-1B / aph(6)-Id / aph(3'')-Ib / tet(B) | mrkA / mrkB / mrkC / mrkD / mrkF / mrkJ | 1..41043 | 41043 | |
| - | flank | IS/Tn | - | - | 6066..6989 | 923 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 11005.83 Da Isoelectric Point: 10.5938
>T230275 WP_000220560.1 NZ_CP090215:10358-10639 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR
Download Length: 282 bp
>T230275 NZ_CP124824:337385-337753 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGGCTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGGCTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9194.43 Da Isoelectric Point: 4.1683
>AT230275 WP_000121743.1 NZ_CP090215:10117-10368 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL
Download Length: 252 bp
>AT230275 NZ_CP124824:337167-337388 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G3CAN5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3S5I301 |