Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 435160..435740 Replicon plasmid unnamed1
Accession NZ_CP090208
Organism Pantoea agglomerans strain HJS002

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LZU96_RS21850 Protein ID WP_233988800.1
Coordinates 435420..435740 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LZU96_RS21845 Protein ID WP_262287750.1
Coordinates 435160..435411 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZU96_RS21820 (LZU96_21820) 430560..430970 - 411 WP_233988679.1 hydroxyisourate hydrolase -
LZU96_RS21825 (LZU96_21825) 431107..431787 + 681 WP_233988680.1 response regulator transcription factor HprR -
LZU96_RS21830 (LZU96_21830) 431780..433135 + 1356 WP_233988681.1 heavy metal sensor histidine kinase -
LZU96_RS21835 (LZU96_21835) 433343..433636 - 294 WP_233988682.1 DUF1330 domain-containing protein -
LZU96_RS21840 (LZU96_21840) 433936..434841 + 906 WP_233988683.1 LysR family transcriptional regulator -
LZU96_RS21845 (LZU96_21845) 435160..435411 + 252 WP_262287750.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LZU96_RS21850 (LZU96_21850) 435420..435740 + 321 WP_233988800.1 endoribonuclease MazF Toxin
LZU96_RS21855 (LZU96_21855) 436381..437640 + 1260 WP_233988685.1 sensor domain-containing diguanylate cyclase -
LZU96_RS21860 (LZU96_21860) 437939..439399 + 1461 WP_262287739.1 MDR family MFS transporter -
LZU96_RS21865 (LZU96_21865) 439435..440445 - 1011 WP_233988686.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..548340 548340


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-102)

Antitoxin

SpoVT-AbrB domain

(9-52)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11501.18 Da        Isoelectric Point: 4.8258

>T230250 WP_233988800.1 NZ_CP090208:435420-435740 [Pantoea agglomerans]
IPAAGDLIWLDVDPQAGHEQAGHRPAVVLSSISYNATGVLICVPVTTKLKGYPFEVELVGDVRSAALADQVCHKDWKAPG
AKFIRKVEPDELEEIRELAQILISTN

Download         Length: 321 bp

>T230250 NZ_CP124816:14154-14570 [Citrobacter freundii]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9347.65 Da        Isoelectric Point: 7.0147

>AT230250 WP_262287750.1 NZ_CP090208:435160-435411 [Pantoea agglomerans]
IDGYRNREKWGNSPAIRLTADVMRAANLNVDDRVEITVVEGQLTVRPVKKRPTLAELVARITPENMHDAVEWRAPVGKEI
NEG

Download         Length: 252 bp

>AT230250 NZ_CP124816:13927-14157 [Citrobacter freundii]
ATGCGCACAGTTTCAATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References