Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3227862..3228480 Replicon chromosome
Accession NZ_CP090207
Organism Pantoea agglomerans strain HJS002

Toxin (Protein)


Gene name Hha Uniprot ID A0A653W0R0
Locus tag LZU96_RS15505 Protein ID WP_031374659.1
Coordinates 3228265..3228480 (+) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A653VZU9
Locus tag LZU96_RS15500 Protein ID WP_031374658.1
Coordinates 3227862..3228239 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZU96_RS15470 (LZU96_15470) 3224162..3224416 + 255 WP_233985096.1 type B 50S ribosomal protein L31 -
LZU96_RS15475 (LZU96_15475) 3224428..3224568 + 141 WP_233985097.1 type B 50S ribosomal protein L36 -
LZU96_RS15480 (LZU96_15480) 3224613..3225491 - 879 WP_233985098.1 metal ABC transporter substrate-binding protein -
LZU96_RS15485 (LZU96_15485) 3225507..3226346 - 840 WP_233985099.1 metal ABC transporter permease -
LZU96_RS15490 (LZU96_15490) 3226343..3227011 - 669 WP_233985100.1 ATP-binding cassette domain-containing protein -
LZU96_RS15495 (LZU96_15495) 3227361..3227714 + 354 WP_233988214.1 hypothetical protein -
LZU96_RS15500 (LZU96_15500) 3227862..3228239 + 378 WP_031374658.1 Hha toxicity modulator TomB Antitoxin
LZU96_RS15505 (LZU96_15505) 3228265..3228480 + 216 WP_031374659.1 HHA domain-containing protein Toxin
LZU96_RS15515 (LZU96_15515) 3228894..3229205 + 312 WP_233985101.1 MGMT family protein -
LZU96_RS15520 (LZU96_15520) 3229242..3229799 - 558 WP_233985102.1 YbaY family lipoprotein -
LZU96_RS15525 (LZU96_15525) 3229990..3230853 + 864 WP_233985103.1 acyl-CoA thioesterase II -
LZU96_RS15530 (LZU96_15530) 3230901..3232187 - 1287 WP_069727946.1 ammonium transporter AmtB -
LZU96_RS15535 (LZU96_15535) 3232221..3232559 - 339 WP_003850469.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8523.90 Da        Isoelectric Point: 9.4825

>T230249 WP_031374659.1 NZ_CP090207:3228265-3228480 [Pantoea agglomerans]
MNKNLTKTDYLMRLRRCRSIDTLERVIEKNKYELPEDELAVFYSAADHRLAELTMNKLYDKVPGSVWKFVR

Download         Length: 216 bp

>T230249 NZ_CP124813:c4842074-4841700 [Citrobacter freundii]
ATGGTCAAAGGATCCGCGCTTTTTGATACCAACATCCTCATCGATCTGTTTAGTGGGAGAAATGAAGCAAAACTAGCGAT
AGAAACATGGCCGCCGCAGAATGCAATCAGCCTCATTACATGGATGGAGGTGATGGTGGGTGCAAAAAAATACCATCAGG
AAGCCCGTACTCGTGTTGCGCTAGGTGCTTTTAACGTGATCGGCGTTTCACAGGATATTGCTGAACGAAGCGTGAGTATC
AGACAGGAATATGGGATGAAATTGCCGGATGCCATTATTTTGGCAACAGCACAGATTCATCGTCTTACGCTGGTTACGCG
AAATACTAAGGATTTTGCAGGCCTATCCGGTGTGGTCACACCGTATACATTATAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14695.32 Da        Isoelectric Point: 4.4069

>AT230249 WP_031374658.1 NZ_CP090207:3227862-3228239 [Pantoea agglomerans]
MDEYSPKRHDIAQLKYLCESLFDESMATLTDSHHGWVNDPTSESNLQLNDLIEHIASFTMNYKIKHVEDEALISQIDEYL
DDTFMLFSNYGVNTQDLQRWQRSAKRLFNLFTEECAFLQQPSHSL

Download         Length: 378 bp

>AT230249 NZ_CP124813:c4842316-4842074 [Citrobacter freundii]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGATGAAGTGATTAAACGTCTTGATGATCTCAAGGT
GCAGCGCAACCTGCCGCGAGCAGAACTTTTACGGGAGGCCGTTGAACAGTATCTTGAGAGACAGGATCAGGCTGAAACCA
CAATTTCACGTGCTCTTGGGCTGTGGCAAGGCTGTGAGGAAGATGGTGTTGAATACCAGCGTAAACTCCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A653W0R0

Antitoxin

Source ID Structure
AlphaFold DB A0A653VZU9

References