Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2305505..2306138 Replicon chromosome
Accession NZ_CP090207
Organism Pantoea agglomerans strain HJS002

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LZU96_RS10945 Protein ID WP_233984383.1
Coordinates 2305857..2306138 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LZU96_RS10940 Protein ID WP_233984382.1
Coordinates 2305505..2305864 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZU96_RS10930 (LZU96_10930) 2301075..2302229 + 1155 WP_233984380.1 efflux RND transporter periplasmic adaptor subunit -
LZU96_RS10935 (LZU96_10935) 2302242..2305394 + 3153 WP_233984381.1 multidrug efflux RND transporter permease subunit OqxB -
LZU96_RS10940 (LZU96_10940) 2305505..2305864 - 360 WP_233984382.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LZU96_RS10945 (LZU96_10945) 2305857..2306138 - 282 WP_233984383.1 type II toxin-antitoxin system HicA family toxin Toxin
LZU96_RS10950 (LZU96_10950) 2306288..2306782 - 495 WP_233984384.1 Rrf2 family transcriptional regulator -
LZU96_RS10955 (LZU96_10955) 2306989..2308173 - 1185 WP_233984385.1 MFS transporter -
LZU96_RS10960 (LZU96_10960) 2308378..2309307 + 930 WP_233984386.1 DNA replication terminus site-binding protein -
LZU96_RS10965 (LZU96_10965) 2309357..2310754 - 1398 WP_233984387.1 class II fumarate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10379.93 Da        Isoelectric Point: 11.2906

>T230248 WP_233984383.1 NZ_CP090207:c2306138-2305857 [Pantoea agglomerans]
MNDAINALRKKQRETLLQIFQTPPPSGVKWQAIESLIRALGGQIKQGSGSRVRFLLSGKIARFHRPHPSPDTDKGAIISL
REWLESTGVNPHE

Download         Length: 282 bp

>T230248 NZ_CP124813:c4658699-4658340 [Citrobacter freundii]
ATGACGAAACCACTTTACTGGGTTGGGCAGGCCAGAAAAGACCTGATTGCAATGCCAGAACACGTTCGGGATACGTTTGG
GTTTGCTCTTTGGCTTGCGCAACAGGGTAAACAGCATTCACAGACTAAACCATTAAAAGGATTTGGTGGAGCGGGGGTTC
TGGAAGTCGTTGAGGATTATCACGGCAACGCCTGGCGGGCGGTTTACACCATCCAGTTGAAAAATGCGGTTTATGTTCTC
CATGTTTTTCAGAAGAAGTCCGTTTCCGGGAAAGCAACCCCGAAACCTGAAATTGACCTGATTTATCAGCGGCTCAAGGC
TGCACAGCGCCATGCGCAGGAGAGTGGATATGTCACATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13231.94 Da        Isoelectric Point: 5.1485

>AT230248 WP_233984382.1 NZ_CP090207:c2305864-2305505 [Pantoea agglomerans]
MNSRVNTSTITVAGQPAVISYVPEINMFRGRFLGLSGYCDFVSDSVQGLHKEGEISLREYLEDCVASGVNPYAEQEKIKT
FTLRYPESLGERLSQAAAQNQTSLNAFIIETLNEKLKHV

Download         Length: 360 bp

>AT230248 NZ_CP124813:c4658350-4658033 [Citrobacter freundii]
ATGTCACATGATGTCGAAACCAGTAGCGGTAATGTTTACGCCGATTTAGGTGCGTATGACGCAGAACAGATGCAGTTGAA
AGCGCAGCTGGCAATGGTGATTGGTGAGATTTTGCAACGCAAAGGGTTAACGCAGCAGCAGGCCGCGCAGTTACTGGGAA
TGACACAGCCTAAACTTTCCAATCTGCTACGCGGCCAGTTTCGCGGTATCAGTGAAGCAAAGATGCTCGAATGCCTGGTG
AGGCTGGGCCGTGATGTAGAGATTGTTGTCGGGAAAGAGGGCAATATGTCAGGAAAGCTGAAAGTGAAATTTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References