Detailed information of TA system TA230247

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2191916..2193477
• Replicon: chromosome
• Accession: NZ_CP090207
• Organism: Pantoea agglomerans strain HJS002

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LZU96_RS10415
• Protein ID: WP_233984287.1
• Coordinates: 2192164..2193477 (+)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LZU96_RS10410
• Protein ID: WP_233984286.1
• Coordinates: 2191916..2192164 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZU96_RS10390 (LZU96_10390)	2187148..2189367	+	2220	WP_233984282.1	iron ABC transporter permease	-
LZU96_RS10395 (LZU96_10395)	2189364..2190425	+	1062	WP_233984283.1	ABC transporter ATP-binding protein	-
LZU96_RS10400 (LZU96_10400)	2190450..2191244	+	795	WP_233984284.1	inositol monophosphatase	-
LZU96_RS10405 (LZU96_10405)	2191293..2191727	-	435	WP_233984285.1	GNAT family N-acetyltransferase	-
LZU96_RS10410 (LZU96_10410)	2191916..2192164	+	249	WP_233984286.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LZU96_RS10415 (LZU96_10415)	2192164..2193477	+	1314	WP_233984287.1	type II toxin-antitoxin system HipA family toxin	Toxin
LZU96_RS10420 (LZU96_10420)	2193565..2194965	+	1401	WP_233988174.1	M24 family metallopeptidase	-
LZU96_RS10425 (LZU96_10425)	2195028..2195666	+	639	WP_233984288.1	LysE family translocator	-
LZU96_RS10430 (LZU96_10430)	2195813..2197858	+	2046	WP_233984289.1	FUSC family protein	-
LZU96_RS10435 (LZU96_10435)	2198079..2198330	+	252	WP_233984290.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-393)

Antitoxin

• Cro/C1-type helix-turn-helix domain (9-54)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 48975.64 Da
• Isoelectric Point: 9.1590

>T230247 WP_233984287.1 NZ_CP090207:2192164-2193477 [Pantoea agglomerans]
MQKLIAWMNGERVGVLTRQRNGAHEFQYDKAWLSNPLARPLSLSMPLQVPVITSHAVINFFDNLLPDSPLIRDRIVARYQ
IKSRQPFDLLQEVGRDSVGATMLLPPEMPLPPLQVRYELLDEARLESVLSAYQSDIPLGMLREETDFRISVAGAQEKTAL
LHTEQGWSIPAGATPTSHIIKLPIGEIKQPAATLDMRESVENEYLCLALARALGLNVPQASIIRAGAMRALAVERFDRRW
SRDRTRLIRLPQEDFCQALGLPSSTKYESDGGPGIAEIMQLLMGSSNAIEDRYHFMMFQVFQWLIGATDGHAKNFSLFIE
RGGSYRLTPFYDVISAYPVLGGTGLNKRALKLAMGLRASKGKKTEIDKIFPRHFFATAKSVNFDSGSLQQIFDFFIRAFP
PAVIAVRDALPAGFPQHIADAIFSHSLIMLERLRQKD

Nucleotide

• Length: 1314 bp

>T230247 NZ_CP124813:c4098928-4098521 [Citrobacter freundii]
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTATTCGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCCTGTCAGGGTGAGATTCGGCTGTTGATGGATGGTCGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATCGTTAGCGCCCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGCTCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCGGCAGACAGTATGGATGATGCTGAGTGGCGGGATTTACGGCGGTTGATGCTGCAAAAGGCGAAGC
AGAAGTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9304.69 Da
• Isoelectric Point: 5.7833

>AT230247 WP_233984286.1 NZ_CP090207:2191916-2192164 [Pantoea agglomerans]
MIYSPLQLANRLKLIRQRNGWTQSELAKKVGLKQATISHFENAPDNTSLATLFKLLQSLELSLEVQEKMVAAPPPLNDED
DW

Nucleotide

• Length: 249 bp

>AT230247 NZ_CP124813:c4099175-4098909 [Citrobacter freundii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGCGAGCTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTGAGCTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA