Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 107517..108187 | Replicon | plasmid pJNKPN26_Vir |
| Accession | NZ_CP090206 | ||
| Organism | Klebsiella pneumoniae strain JNKPN26 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | Q6U619 |
| Locus tag | LXM99_RS29375 | Protein ID | WP_004213072.1 |
| Coordinates | 107517..107960 (-) | Length | 148 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | Q6U620 |
| Locus tag | LXM99_RS29380 | Protein ID | WP_004213073.1 |
| Coordinates | 107957..108187 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LXM99_RS29340 (LXM99_29340) | 102928..103203 | + | 276 | WP_004213932.1 | carboxymuconolactone decarboxylase family protein | - |
| LXM99_RS29345 (LXM99_29345) | 103266..103757 | + | 492 | WP_011251327.1 | DM13 domain-containing protein | - |
| LXM99_RS29350 (LXM99_29350) | 103806..104726 | + | 921 | WP_004213934.1 | DUF1471 domain-containing protein | - |
| LXM99_RS29355 (LXM99_29355) | 104817..105220 | + | 404 | Protein_120 | GAF domain-containing protein | - |
| LXM99_RS29360 (LXM99_29360) | 105738..106373 | - | 636 | Protein_121 | mucoid phenotype regulator RmpA2 | - |
| LXM99_RS29365 (LXM99_29365) | 106790..107094 | + | 305 | Protein_122 | transposase | - |
| LXM99_RS29370 (LXM99_29370) | 107117..107368 | - | 252 | WP_186987481.1 | hypothetical protein | - |
| LXM99_RS29375 (LXM99_29375) | 107517..107960 | - | 444 | WP_004213072.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LXM99_RS29380 (LXM99_29380) | 107957..108187 | - | 231 | WP_004213073.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| LXM99_RS29385 (LXM99_29385) | 108795..109928 | + | 1134 | WP_004213075.1 | DUF3800 domain-containing protein | - |
| LXM99_RS29390 (LXM99_29390) | 109944..110237 | + | 294 | WP_004213076.1 | hypothetical protein | - |
| LXM99_RS29395 (LXM99_29395) | 110227..110433 | - | 207 | WP_004213077.1 | hypothetical protein | - |
| LXM99_RS29400 (LXM99_29400) | 110642..110905 | + | 264 | Protein_129 | hypothetical protein | - |
| LXM99_RS29405 (LXM99_29405) | 111405..112226 | + | 822 | WP_004213562.1 | hypothetical protein | - |
| LXM99_RS29410 (LXM99_29410) | 112223..113002 | + | 780 | WP_004213560.1 | site-specific integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 | 1..220975 | 220975 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 148 a.a. Molecular weight: 16006.74 Da Isoelectric Point: 9.3642
>T230244 WP_004213072.1 NZ_CP090206:c107960-107517 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
Download Length: 444 bp
>T230244 NZ_CP124813:c1220978-1220760 [Citrobacter freundii]
ATGTCCGATAAACCATTAACTAAAACAGATTATTTGATGCGCCTGCGACGTTGCCAGACAATTGATACGCTAGAGCGCGT
TATTGAAAAAAATAAATATGAATTGTCCGACAACGAACTGGCTGTATTTTACTCAGCAGCAGATCATCGCCTTGCTGAAT
TGACCATGAATAAGCTTTACGACAAGATTCCAACTTCTGTTTGGAAATTCATTCGCTAA
ATGTCCGATAAACCATTAACTAAAACAGATTATTTGATGCGCCTGCGACGTTGCCAGACAATTGATACGCTAGAGCGCGT
TATTGAAAAAAATAAATATGAATTGTCCGACAACGAACTGGCTGTATTTTACTCAGCAGCAGATCATCGCCTTGCTGAAT
TGACCATGAATAAGCTTTACGACAAGATTCCAACTTCTGTTTGGAAATTCATTCGCTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8677.73 Da Isoelectric Point: 4.4563
>AT230244 WP_004213073.1 NZ_CP090206:c108187-107957 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT230244 NZ_CP124813:c1221380-1221006 [Citrobacter freundii]
ATGGATGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAATTTCTCTGCGAAACTCTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGTAACCATGGCTGGGTTAATGACCCTACCTCTGCAACCAGCTTGCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGATCGCGCAGATAGATGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGTATTAATACGCAGGATCTGCAGAAATGGCGGAAGTCAGGTAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA
ATGGATGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAATTTCTCTGCGAAACTCTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGTAACCATGGCTGGGTTAATGACCCTACCTCTGCAACCAGCTTGCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGATCGCGCAGATAGATGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGTATTAATACGCAGGATCTGCAGAAATGGCGGAAGTCAGGTAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|