Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RelE-RHH |
| Location | 26392..26939 | Replicon | plasmid p1 |
| Accession | NZ_CP090197 | ||
| Organism | Escherichia coli strain YL3 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | LXN07_RS24630 | Protein ID | WP_244449344.1 |
| Coordinates | 26661..26939 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | E2GHF7 |
| Locus tag | LXN07_RS24625 | Protein ID | WP_012881119.1 |
| Coordinates | 26392..26661 (+) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LXN07_RS24580 (21408) | 21408..21869 | + | 462 | WP_001233838.1 | thermonuclease family protein | - |
| LXN07_RS24585 (21915) | 21915..22124 | + | 210 | WP_001298565.1 | hemolysin expression modulator Hha | - |
| LXN07_RS24590 (22162) | 22162..22752 | + | 591 | WP_033807967.1 | DUF2726 domain-containing protein | - |
| LXN07_RS24595 (22907) | 22907..23380 | + | 474 | WP_016240489.1 | hypothetical protein | - |
| - (23523) | 23523..23582 | - | 60 | NuclAT_1 | - | - |
| - (23523) | 23523..23582 | - | 60 | NuclAT_1 | - | - |
| - (23523) | 23523..23582 | - | 60 | NuclAT_1 | - | - |
| - (23523) | 23523..23582 | - | 60 | NuclAT_1 | - | - |
| LXN07_RS24600 (23627) | 23627..23776 | + | 150 | WP_001312851.1 | Hok/Gef family protein | - |
| LXN07_RS24605 (24061) | 24061..24309 | + | 249 | WP_000083839.1 | replication regulatory protein RepA | - |
| LXN07_RS24610 (24554) | 24554..24628 | + | 75 | WP_001365705.1 | RepA leader peptide Tap | - |
| LXN07_RS24615 (24621) | 24621..25478 | + | 858 | WP_016240488.1 | incFII family plasmid replication initiator RepA | - |
| LXN07_RS24620 (26179) | 26179..26337 | + | 159 | WP_032142560.1 | hypothetical protein | - |
| LXN07_RS24625 (26392) | 26392..26661 | + | 270 | WP_012881119.1 | type II toxin-antitoxin system antitoxin YacA | Antitoxin |
| LXN07_RS24630 (26661) | 26661..26939 | + | 279 | WP_244449344.1 | type II toxin-antitoxin system toxin YacB | Toxin |
| LXN07_RS24635 (26985) | 26985..27833 | + | 849 | WP_012881117.1 | 3'-5' exonuclease | - |
| LXN07_RS24640 (27950) | 27950..28432 | + | 483 | WP_001311056.1 | hypothetical protein | - |
| LXN07_RS24645 (28461) | 28461..29537 | - | 1077 | WP_077252865.1 | maltoporin | - |
| LXN07_RS24650 (29538) | 29538..29945 | - | 408 | Protein_34 | IS5 family transposase | - |
| LXN07_RS24655 (30025) | 30025..30900 | - | 876 | WP_001617865.1 | extended-spectrum class A beta-lactamase CTX-M-14 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaCTX-M-14 | - | 1..97598 | 97598 | |
| - | flank | IS/Tn | blaCTX-M-14 | - | 30025..32412 | 2387 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10744.34 Da Isoelectric Point: 8.4615
>T230211 WP_244449344.1 NZ_CP090197:26661-26939 [Escherichia coli]
MEIFWTILASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP
MEIFWTILASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP
Download Length: 279 bp
>T230211 NZ_CP124754:4520054-4520365 [Serratia sp. K-E0102]
ATGCATATCATTTCCAGGGAGCCGTTCAATAACGCAACCAAGCAATACCCTAATGAAGCCGCTGCTCTCGAGGCCATTTA
TAAAGCGTTGCGACGCGGCGAGTTCCGCACGCCGGACGAGTTAAAAGCGCTTTTTCCTTCGCTCGATCGTATGAAATACA
AAGAGAAATGGTGGGTCATTGACGTCGGCGGCAACCACCTGCGGATTTTGTTCTTCGCCAGCTTCGAGACACAGAAAGTC
TTCATAAAGCATATCGTTAGCCACGCCGAGTACGACAAGCTGATGCAGCACTATCGAAGGAGTTCATCATGA
ATGCATATCATTTCCAGGGAGCCGTTCAATAACGCAACCAAGCAATACCCTAATGAAGCCGCTGCTCTCGAGGCCATTTA
TAAAGCGTTGCGACGCGGCGAGTTCCGCACGCCGGACGAGTTAAAAGCGCTTTTTCCTTCGCTCGATCGTATGAAATACA
AAGAGAAATGGTGGGTCATTGACGTCGGCGGCAACCACCTGCGGATTTTGTTCTTCGCCAGCTTCGAGACACAGAAAGTC
TTCATAAAGCATATCGTTAGCCACGCCGAGTACGACAAGCTGATGCAGCACTATCGAAGGAGTTCATCATGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10206.54 Da Isoelectric Point: 8.8735
>AT230211 WP_012881119.1 NZ_CP090197:26392-26661 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSATAWRD
EISRKVAGK
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSATAWRD
EISRKVAGK
Download Length: 270 bp
>AT230211 NZ_CP124754:4520362-4520784 [Serratia sp. K-E0102]
ATGATTACAGATGCCATTAAGGCCGCCGATGCGCTGCTGCGCGCCGTGCCCTTATTGCAGGGCAGCAGCTCTCAGCAAGA
CTACCGGGAAGCGCTCGAATTGGTGGAATATCTGCTGGAAAACGATGAACACCATCCGCTGATTGACATGCTGGCAAAAA
AAATCGCCGAATATGAAGATAACAGCGCCGAATTTACCGCATTCAACCAGCGTATCGCCCAACTCCCGCAAGGAGTGGCC
GCGCTTCGCGTATTGATGGAACAACACCAACTTAGCCAAAGTGATTTTGAACATGAGATCGGTAAAAAGTCGTTGGTCAG
CCAAATCCTGAGTGGCAAAAGATCGCTGACCATTCCGCACATTATGGCGCTGGCCAAACGCTTCAATCTGCCCCCGGCCC
TCTTCCTGCCGGAAGCGGATTAG
ATGATTACAGATGCCATTAAGGCCGCCGATGCGCTGCTGCGCGCCGTGCCCTTATTGCAGGGCAGCAGCTCTCAGCAAGA
CTACCGGGAAGCGCTCGAATTGGTGGAATATCTGCTGGAAAACGATGAACACCATCCGCTGATTGACATGCTGGCAAAAA
AAATCGCCGAATATGAAGATAACAGCGCCGAATTTACCGCATTCAACCAGCGTATCGCCCAACTCCCGCAAGGAGTGGCC
GCGCTTCGCGTATTGATGGAACAACACCAACTTAGCCAAAGTGATTTTGAACATGAGATCGGTAAAAAGTCGTTGGTCAG
CCAAATCCTGAGTGGCAAAAGATCGCTGACCATTCCGCACATTATGGCGCTGGCCAAACGCTTCAATCTGCCCCCGGCCC
TCTTCCTGCCGGAAGCGGATTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|