Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 806572..807055 Replicon chromosome
Accession NC_011134
Organism Streptococcus equi subsp. zooepidemicus MGCS10565

Toxin (Protein)


Gene name relE Uniprot ID B4U2C0
Locus tag SEZ_RS03855 Protein ID WP_012515411.1
Coordinates 806795..807055 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4U2B9
Locus tag SEZ_RS03850 Protein ID WP_012515410.1
Coordinates 806572..806793 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SEZ_RS03830 803098..803373 + 276 WP_012515407.1 hypothetical protein -
SEZ_RS03835 803557..804012 - 456 WP_041785400.1 DUF1694 domain-containing protein -
SEZ_RS03840 804244..805551 + 1308 WP_012515409.1 phosphopyruvate hydratase -
SEZ_RS09790 805790..805879 + 90 WP_111677961.1 type I toxin-antitoxin system Fst family toxin -
SEZ_RS03845 806126..806362 - 237 Protein_720 transposase -
SEZ_RS03850 806572..806793 + 222 WP_012515410.1 hypothetical protein Antitoxin
SEZ_RS03855 806795..807055 + 261 WP_012515411.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SEZ_RS09620 807135..808111 + 977 Protein_723 IS3 family transposase -
SEZ_RS09855 808112..808366 + 255 Protein_724 HAD family hydrolase -
SEZ_RS03875 808836..811616 + 2781 WP_012515415.1 endonuclease/exonuclease/phosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 807135..807650 515


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10275.81 Da        Isoelectric Point: 9.8428

>T23021 WP_012515411.1 NC_011134:806795-807055 [Streptococcus equi subsp. zooepidemicus MGCS10565]
MYRIEYSKKAQKQIKKVDKQIQRLLFAWIDKYLEGTDNPRANGKGLAGNHANEWRYRIGDYRLICDIQDDKMVVLALEFG
HRRDVY

Download         Length: 261 bp

>T23021 NC_011134:806795-807055 [Streptococcus equi subsp. zooepidemicus MGCS10565]
ATGTACCGTATAGAGTATTCTAAAAAGGCTCAAAAGCAGATTAAGAAAGTAGATAAGCAAATTCAGAGGTTGCTATTTGC
TTGGATTGATAAGTATTTAGAGGGAACAGATAACCCACGCGCAAATGGTAAGGGTTTGGCAGGAAATCATGCTAATGAGT
GGCGTTATCGTATTGGTGATTATAGGCTTATTTGTGATATTCAAGATGATAAGATGGTTGTTTTAGCGCTTGAGTTTGGG
CATAGGCGAGATGTTTATTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8536.57 Da        Isoelectric Point: 4.6104

>AT23021 WP_012515410.1 NC_011134:806572-806793 [Streptococcus equi subsp. zooepidemicus MGCS10565]
MSTVTIRLNQEEEIFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYAEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT23021 NC_011134:806572-806793 [Streptococcus equi subsp. zooepidemicus MGCS10565]
ATGAGTACAGTTACTATCAGATTAAATCAAGAAGAAGAAATATTTTTCAAAAGTTATGCTCAACTCACAGGGCAAAGTTT
ATCAAGTCTATTTAAAAAAGCTCTTGAGCGGGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCCTATGCTG
AATATAAAGCAGACCCTGAGACAATTAGCCATGCTGATTTTAAGAAAGAGCTAGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4U2C0

Antitoxin

Source ID Structure
AlphaFold DB A0A380KCN4

References