230203

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3801865..3802483 Replicon chromosome
Accession NZ_CP090196
Organism Escherichia coli strain YL3

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LXN07_RS18300 Protein ID WP_001291435.1
Coordinates 3802265..3802483 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LXN07_RS18295 Protein ID WP_000344800.1
Coordinates 3801865..3802239 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXN07_RS18285 (3796954) 3796954..3798147 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LXN07_RS18290 (3798170) 3798170..3801319 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
LXN07_RS18295 (3801865) 3801865..3802239 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LXN07_RS18300 (3802265) 3802265..3802483 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LXN07_RS18305 (3802655) 3802655..3803206 + 552 WP_001522034.1 maltose O-acetyltransferase -
LXN07_RS18310 (3803322) 3803322..3803792 + 471 WP_001490888.1 YlaC family protein -
LXN07_RS18315 (3803956) 3803956..3805506 + 1551 WP_001577872.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LXN07_RS18320 (3805548) 3805548..3805901 - 354 WP_000878140.1 DUF1428 domain-containing protein -
LXN07_RS18330 (3806280) 3806280..3806591 + 312 WP_000409911.1 MGMT family protein -
LXN07_RS18335 (3806622) 3806622..3807194 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T230203 WP_001291435.1 NZ_CP090196:3802265-3802483 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T230203 NZ_CP124754:c1456933-1456628 [Serratia sp. K-E0102]
ATGCCCGCGTTTCGCCTCACCCCGCAAGCCCAACAAGATCTGCTGGCTATTCGCCATTTCACCGTCGAGCACTGGGGCCA
AACGCAATCTCGCCGCTATCTTGAGCAGTTGAGAGAGATCATGCATCATCTGGCGGACATGCCGGAAGCGGGTAAAGCCC
ACTTTCACGATCTGGGCGAAGAGATACGCAGTTTTCCTTACGCCAGCCATAGGATCTACTACCGCAGCCGCCCTGCCGGC
ATCACCGTTCTTGCCATTTTGCATCAGGCGATGGTACCCCACCGGCATCTGGAACAACGGCTGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT230203 WP_000344800.1 NZ_CP090196:3801865-3802239 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT230203 NZ_CP124754:c1457195-1456935 [Serratia sp. K-E0102]
ATGTACGCACTCAGCGCGAACGAGGCCAAAACCCAATTCGGCGATTTGCTGCTCAAGGCGCAGCGCGAACCGGTGCAAAT
CAATCGCAACGGCAAACCGGTCGCCGTCGTCATGTCGGTAGAAGACTACCAGGCGCTGGAAGATCTCAAACTACGCGCGC
TGCAGCAAAAAATCGCGCAGGCTACCGCCGAGGAAGACGCCGGTAAGGCGGTAGACGGTGATGCCTTCTTCAACCGTCTG
CTCACCGATGAAACCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References