Detailed information of TA system TA230202

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 3379468..3380173
• Replicon: chromosome
• Accession: NZ_CP090196
• Organism: Escherichia coli strain YL3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1F406
• Locus tag: LXN07_RS16440
• Protein ID: WP_000539521.1
• Coordinates: 3379468..3379854 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LXN07_RS16445
• Protein ID: WP_001280945.1
• Coordinates: 3379844..3380173 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXN07_RS16420 (3375472)	3375472..3376098	+	627	WP_020233670.1	glutathione S-transferase GstB	-
LXN07_RS16425 (3376095)	3376095..3377210	-	1116	WP_000555050.1	aldose sugar dehydrogenase YliI	-
LXN07_RS16430 (3377321)	3377321..3377704	-	384	WP_000497137.1	biofilm formation regulator BssR	-
LXN07_RS16435 (3377917)	3377917..3379242	+	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
LXN07_RS16440 (3379468)	3379468..3379854	+	387	WP_000539521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LXN07_RS16445 (3379844)	3379844..3380173	+	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
LXN07_RS16450 (3380243)	3380243..3381571	-	1329	Protein_3228	diguanylate cyclase	-
LXN07_RS16455 (3381579)	3381579..3383927	-	2349	WP_021523051.1	EAL domain-containing protein	-
LXN07_RS16460 (3384105)	3384105..3385016	-	912	WP_001236019.1	glutathione ABC transporter permease GsiD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14293.45 Da
• Isoelectric Point: 9.9296

>T230202 WP_000539521.1 NZ_CP090196:3379468-3379854 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T230202 NZ_CP124754:c1062444-1062241 [Serratia sp. K-E0102]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCGGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT230202 WP_001280945.1 NZ_CP090196:3379844-3380173 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT230202 NZ_CP124754:c1062862-1062494 [Serratia sp. K-E0102]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCACCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCAGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Structures

Toxin

• AlphaFold DB: A0A829GCT6