Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2477437..2477963 | Replicon | chromosome |
| Accession | NZ_CP090196 | ||
| Organism | Escherichia coli strain YL3 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | LXN07_RS11850 | Protein ID | WP_000323025.1 |
| Coordinates | 2477676..2477963 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | LXN07_RS11845 | Protein ID | WP_000534858.1 |
| Coordinates | 2477437..2477676 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LXN07_RS11815 (2472699) | 2472699..2473313 | + | 615 | WP_001265627.1 | hypothetical protein | - |
| LXN07_RS11820 (2473316) | 2473316..2474338 | + | 1023 | WP_000915483.1 | DUF4868 domain-containing protein | - |
| LXN07_RS11825 (2474843) | 2474843..2475865 | + | 1023 | Protein_2314 | ISNCY family transposase | - |
| LXN07_RS11830 (2475986) | 2475986..2476135 | + | 150 | WP_011443592.1 | protein YdfW | - |
| LXN07_RS11835 (2476572) | 2476572..2476904 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| LXN07_RS11840 (2477107) | 2477107..2477412 | - | 306 | WP_001326990.1 | protein YdfV | - |
| LXN07_RS11845 (2477437) | 2477437..2477676 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| LXN07_RS11850 (2477676) | 2477676..2477963 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| LXN07_RS11855 (2478035) | 2478035..2478190 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| LXN07_RS11860 (2478407) | 2478407..2478658 | + | 252 | WP_000980994.1 | protein Rem | - |
| LXN07_RS11865 (2478725) | 2478725..2479003 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| LXN07_RS11870 (2479005) | 2479005..2480054 | + | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| LXN07_RS11875 (2480068) | 2480068..2480820 | + | 753 | WP_001047135.1 | antitermination protein | - |
| LXN07_RS11880 (2481098) | 2481098..2481187 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| LXN07_RS11885 (2481242) | 2481242..2481454 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| LXN07_RS11890 (2481755) | 2481755..2481970 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| LXN07_RS11895 (2482334) | 2482334..2482504 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| LXN07_RS11900 (2482724) | 2482724..2482939 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2457887..2510144 | 52257 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T230199 WP_000323025.1 NZ_CP090196:2477676-2477963 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T230199 NZ_CP124754:c15096-14716 [Serratia sp. K-E0102]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAACAGGGGCCGG
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAACTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTGTCTGGGCCACCGCGCAGGTGGGGTTCCGAACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTACCGGCTGTAG
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAACAGGGGCCGG
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAACTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTGTCTGGGCCACCGCGCAGGTGGGGTTCCGAACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTACCGGCTGTAG
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT230199 WP_000534858.1 NZ_CP090196:2477437-2477676 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT230199 NZ_CP124754:c15317-15096 [Serratia sp. K-E0102]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGACGGAGAACCACGTTGAAGATCCCAGCAATGCTTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGACGGAGAACCACGTTGAAGATCCCAGCAATGCTTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|