Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1974304..1975135 Replicon chromosome
Accession NZ_CP090196
Organism Escherichia coli strain YL3

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag LXN07_RS09260 Protein ID WP_000854814.1
Coordinates 1974304..1974678 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag LXN07_RS09265 Protein ID WP_001285585.1
Coordinates 1974767..1975135 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXN07_RS09220 (1969700) 1969700..1970866 + 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
LXN07_RS09225 (1970985) 1970985..1971458 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
LXN07_RS09230 (1971656) 1971656..1972714 + 1059 WP_001200891.1 FUSC family protein -
LXN07_RS09235 (1972886) 1972886..1973215 + 330 WP_000450409.1 DUF496 family protein -
LXN07_RS09240 (1973316) 1973316..1973450 - 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
LXN07_RS09245 (1973570) 1973570..1973698 + 129 Protein_1809 transposase domain-containing protein -
LXN07_RS09250 (1973987) 1973987..1974067 - 81 Protein_1810 hypothetical protein -
LXN07_RS09255 (1974113) 1974113..1974307 - 195 WP_000988600.1 DUF5983 family protein -
LXN07_RS09260 (1974304) 1974304..1974678 - 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
LXN07_RS09265 (1974767) 1974767..1975135 - 369 WP_001285585.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
LXN07_RS09270 (1975209) 1975209..1975430 - 222 WP_000692323.1 DUF987 domain-containing protein -
LXN07_RS09275 (1975499) 1975499..1975975 - 477 WP_001186193.1 RadC family protein -
LXN07_RS09280 (1975991) 1975991..1976470 - 480 WP_089551765.1 antirestriction protein -
LXN07_RS09285 (1976552) 1976552..1977370 - 819 WP_032250973.1 DUF932 domain-containing protein -
LXN07_RS09290 (1977470) 1977470..1977703 - 234 WP_001119729.1 DUF905 family protein -
LXN07_RS09295 (1977761) 1977761..1977979 + 219 Protein_1819 IS66 family insertion sequence element accessory protein TnpB -
LXN07_RS09305 (1979313) 1979313..1979408 + 96 Protein_1821 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T230190 WP_000854814.1 NZ_CP090196:c1974678-1974304 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T230190 NZ_CP124750:1553897-1554211 [Serratia sp. K-M0706]
ATGCAATTTACGGTGTATGCGAATAGGGGGAACAGCGCGGTTTATCCCCTGCTGCTTGATGTGACGAGCGATATCATTGG
GCAATTAAATCGTCGAGTTGTGATCCCTTTGTTGCCCGTTGAAAAATACCCTGGGAGTACGCGACCGGAACGCTTGATCC
CGTTGATCAGATTGATTGATGACAACGAGTACGCCGTGATGACATATGAAATGGCCAGCATCCCGGTTCGGGCTTTGGGG
GCCGAGTTTTGTGATGTTTCCCAGTATCGGACCAGGATAAAAGCCGCCATCGACTTTCTTCTTGACGGTATTTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT230190 WP_001285585.1 NZ_CP090196:c1975135-1974767 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT230190 NZ_CP124750:1553658-1553894 [Serratia sp. K-M0706]
ATGCCAGTAAAACAACGAACGACGCAAAGTGTGACCATGACGGTGGAACGCAGTTTGTTGAGCCGTGCGCGTGAGGCGGG
GATTAATCTCAGCGCGACGCTAACTGCTGCTTTAGATGCTGAGTTACGTCAGCATGAGAGGATAAAATGGCAGGAAGAAA
ACCGAGAGGCGCTTGAAGCGCTTAACCGATTTAATGATGAGCATGGTTGCTTTAGCGACGAATACAGGACGTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References