Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 996353..997007 Replicon chromosome
Accession NZ_CP090196
Organism Escherichia coli strain YL3

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag LXN07_RS04775 Protein ID WP_000244781.1
Coordinates 996600..997007 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag LXN07_RS04770 Protein ID WP_000354046.1
Coordinates 996353..996619 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXN07_RS04745 (991513) 991513..992256 + 744 WP_000951966.1 SDR family oxidoreductase -
LXN07_RS04750 (992313) 992313..993746 - 1434 WP_001605840.1 6-phospho-beta-glucosidase BglA -
LXN07_RS04755 (993791) 993791..994102 + 312 WP_001182943.1 N(4)-acetylcytidine aminohydrolase -
LXN07_RS04760 (994266) 994266..994925 + 660 WP_000250283.1 hemolysin III family protein -
LXN07_RS04765 (995121) 995121..996101 - 981 WP_000886102.1 tRNA-modifying protein YgfZ -
LXN07_RS04770 (996353) 996353..996619 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
LXN07_RS04775 (996600) 996600..997007 + 408 WP_000244781.1 protein YgfX Toxin
LXN07_RS04780 (997047) 997047..997568 - 522 WP_001055874.1 flavodoxin FldB -
LXN07_RS04785 (997680) 997680..998576 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
LXN07_RS04790 (998601) 998601..999311 + 711 WP_000715223.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LXN07_RS04795 (999317) 999317..1001050 + 1734 WP_000813232.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T230186 WP_000244781.1 NZ_CP090196:996600-997007 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T230186 NZ_CP124750:55318-55593 [Serratia sp. K-M0706]
ATGGAGTTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGTTAACCGTACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTTGATAATTCTCGCCTGGGTGAAAGACTGGACG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT230186 WP_000354046.1 NZ_CP090196:996353-996619 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT230186 NZ_CP124750:55058-55318 [Serratia sp. K-M0706]
ATGAATACGAAAGTCATCACCGCTCATGTCCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
CTCACGGGGATGGATAGTGAAGCAAGCCCTCACCGCCTGGCTCGAGCAAGAGGAAGAGCGTCGTCGGTTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAATCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAT
CCGCTGCCGGTACCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References