Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 841964..842798 | Replicon | chromosome |
| Accession | NZ_CP090196 | ||
| Organism | Escherichia coli strain YL3 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A8E0IX31 |
| Locus tag | LXN07_RS03990 | Protein ID | WP_000854689.1 |
| Coordinates | 841964..842341 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A1X3JHN3 |
| Locus tag | LXN07_RS03995 | Protein ID | WP_001285598.1 |
| Coordinates | 842418..842798 (-) | Length | 127 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LXN07_RS03950 (837173) | 837173..837652 | + | 480 | Protein_775 | IS3 family transposase | - |
| LXN07_RS03955 (837693) | 837693..837995 | - | 303 | Protein_776 | IS21 family transposase | - |
| LXN07_RS03960 (838344) | 838344..838514 | - | 171 | Protein_777 | IS110 family transposase | - |
| LXN07_RS03965 (838985) | 838985..839878 | - | 894 | WP_001114681.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| LXN07_RS03970 (839871) | 839871..840266 | - | 396 | WP_000208383.1 | DUF6088 family protein | - |
| LXN07_RS03975 (840335) | 840335..841180 | - | 846 | WP_001529401.1 | DUF4942 domain-containing protein | - |
| LXN07_RS03980 (841265) | 841265..841462 | - | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
| LXN07_RS03985 (841479) | 841479..841967 | - | 489 | WP_000761699.1 | DUF5983 family protein | - |
| LXN07_RS03990 (841964) | 841964..842341 | - | 378 | WP_000854689.1 | TA system toxin CbtA family protein | Toxin |
| LXN07_RS03995 (842418) | 842418..842798 | - | 381 | WP_001285598.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LXN07_RS04000 (842848) | 842848..843492 | - | 645 | WP_021566525.1 | hypothetical protein | - |
| LXN07_RS04005 (843511) | 843511..843732 | - | 222 | WP_000692300.1 | DUF987 domain-containing protein | - |
| LXN07_RS04010 (843795) | 843795..844271 | - | 477 | WP_001186774.1 | RadC family protein | - |
| LXN07_RS04015 (844286) | 844286..844771 | - | 486 | WP_000849565.1 | antirestriction protein | - |
| LXN07_RS04020 (844826) | 844826..845644 | - | 819 | WP_001234620.1 | DUF932 domain-containing protein | - |
| LXN07_RS04025 (845745) | 845745..845978 | - | 234 | WP_001119727.1 | DUF905 family protein | - |
| LXN07_RS04030 (846057) | 846057..846512 | - | 456 | WP_064772576.1 | IrmA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | kpsD / kpsE / kpsF | 827632..867548 | 39916 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14042.07 Da Isoelectric Point: 9.1510
>T230185 WP_000854689.1 NZ_CP090196:c842341-841964 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
Download Length: 378 bp
>T230185 NZ_CP124750:c14541-14161 [Serratia sp. K-M0706]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAACAGGGGCCGG
CGCTGGAGTTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAACTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTGTCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTATCGGCTGTAG
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAACAGGGGCCGG
CGCTGGAGTTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAACTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTGTCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTATCGGCTGTAG
Antitoxin
Download Length: 127 a.a. Molecular weight: 13927.72 Da Isoelectric Point: 4.7959
>AT230185 WP_001285598.1 NZ_CP090196:c842798-842418 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE
Download Length: 381 bp
>AT230185 NZ_CP124750:c14762-14541 [Serratia sp. K-M0706]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACATTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGACGGAGAACCACGTTGAAGATCCCAGCAATGCTTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACATTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGACGGAGAACCACGTTGAAGATCCCAGCAATGCTTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|