Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sanaTA/AbiEii-DUF6088 |
| Location | 838985..840266 | Replicon | chromosome |
| Accession | NZ_CP090196 | ||
| Organism | Escherichia coli strain YL3 | ||
Toxin (Protein)
| Gene name | sanaT | Uniprot ID | A0A1X3JHM4 |
| Locus tag | LXN07_RS03965 | Protein ID | WP_001114681.1 |
| Coordinates | 838985..839878 (-) | Length | 298 a.a. |
Antitoxin (Protein)
| Gene name | sanaA | Uniprot ID | V0YCI1 |
| Locus tag | LXN07_RS03970 | Protein ID | WP_000208383.1 |
| Coordinates | 839871..840266 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LXN07_RS03940 (834169) | 834169..834908 | + | 740 | Protein_773 | IS3 family transposase | - |
| LXN07_RS03945 (835581) | 835581..837089 | + | 1509 | WP_001189111.1 | group II intron reverse transcriptase/maturase | - |
| LXN07_RS03950 (837173) | 837173..837652 | + | 480 | Protein_775 | IS3 family transposase | - |
| LXN07_RS03955 (837693) | 837693..837995 | - | 303 | Protein_776 | IS21 family transposase | - |
| LXN07_RS03960 (838344) | 838344..838514 | - | 171 | Protein_777 | IS110 family transposase | - |
| LXN07_RS03965 (838985) | 838985..839878 | - | 894 | WP_001114681.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| LXN07_RS03970 (839871) | 839871..840266 | - | 396 | WP_000208383.1 | DUF6088 family protein | Antitoxin |
| LXN07_RS03975 (840335) | 840335..841180 | - | 846 | WP_001529401.1 | DUF4942 domain-containing protein | - |
| LXN07_RS03980 (841265) | 841265..841462 | - | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
| LXN07_RS03985 (841479) | 841479..841967 | - | 489 | WP_000761699.1 | DUF5983 family protein | - |
| LXN07_RS03990 (841964) | 841964..842341 | - | 378 | WP_000854689.1 | TA system toxin CbtA family protein | - |
| LXN07_RS03995 (842418) | 842418..842798 | - | 381 | WP_001285598.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
| LXN07_RS04000 (842848) | 842848..843492 | - | 645 | WP_021566525.1 | hypothetical protein | - |
| LXN07_RS04005 (843511) | 843511..843732 | - | 222 | WP_000692300.1 | DUF987 domain-containing protein | - |
| LXN07_RS04010 (843795) | 843795..844271 | - | 477 | WP_001186774.1 | RadC family protein | - |
| LXN07_RS04015 (844286) | 844286..844771 | - | 486 | WP_000849565.1 | antirestriction protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | kpsD / kpsE / kpsF | 827632..867548 | 39916 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 298 a.a. Molecular weight: 34298.40 Da Isoelectric Point: 5.9850
>T230184 WP_001114681.1 NZ_CP090196:c839878-838985 [Escherichia coli]
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN
Download Length: 894 bp
>T230184 NZ_CP124744:3970170-3970589 [Proteus mirabilis]
GTGAAAAAAGTCTATATGCTTGATACAAACATTTGTTCTTTTATCATGCGTGAGCAACCTATTTCTTTACTCGAAAAACT
TCAGAAATGTGTAATGAACCACGATACTATTGTCATATCAGCGATTACTTATTCAGAGATGCGCTTTGGAGCAATAGGAA
AAAAAGCATCACCTAAACACAATCGTTTGGTTGATGCTTTCTGTGAACGCGTTGACGCGATTTTGGCATGGGATAAAGCG
GCGGTAGACGCAACTACCGTGATAAAAAAATGCTTATCTGATGTGGGATTGCCCATAGGAAATAATGATAGCGCTATTGC
TGGTCATGCTGTCGCGGTTAATGCAATATTGGTAACAAATAATACCCGTGAATTTTCACGAGTTGAAGGACTAAAAATAG
AGGACTGGACTCATGTTTGA
GTGAAAAAAGTCTATATGCTTGATACAAACATTTGTTCTTTTATCATGCGTGAGCAACCTATTTCTTTACTCGAAAAACT
TCAGAAATGTGTAATGAACCACGATACTATTGTCATATCAGCGATTACTTATTCAGAGATGCGCTTTGGAGCAATAGGAA
AAAAAGCATCACCTAAACACAATCGTTTGGTTGATGCTTTCTGTGAACGCGTTGACGCGATTTTGGCATGGGATAAAGCG
GCGGTAGACGCAACTACCGTGATAAAAAAATGCTTATCTGATGTGGGATTGCCCATAGGAAATAATGATAGCGCTATTGC
TGGTCATGCTGTCGCGGTTAATGCAATATTGGTAACAAATAATACCCGTGAATTTTCACGAGTTGAAGGACTAAAAATAG
AGGACTGGACTCATGTTTGA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14608.03 Da Isoelectric Point: 11.3150
>AT230184 WP_000208383.1 NZ_CP090196:c840266-839871 [Escherichia coli]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA
Download Length: 396 bp
>AT230184 NZ_CP124744:3969940-3970173 [Proteus mirabilis]
ATGAGAACGAGAACTGTAGCTGTATTTAAAAACGGAAGTAACCGAGCCATTCGCTTACCTAAAGATTTCGATTTTGATGG
TGTCAATGAACTCGAGATAAGCCGAGATGGGGATTGTATTATTTTACGCCCTGTAAAACCTAACTGGATTTCATTACAAA
ACGAAGAAAAAGCCGATAGTGATTTCTTGCTTGAACGCGATGATGTTATTGAAGAAGGACGAGTTATTCTGTGA
ATGAGAACGAGAACTGTAGCTGTATTTAAAAACGGAAGTAACCGAGCCATTCGCTTACCTAAAGATTTCGATTTTGATGG
TGTCAATGAACTCGAGATAAGCCGAGATGGGGATTGTATTATTTTACGCCCTGTAAAACCTAACTGGATTTCATTACAAA
ACGAAGAAAAAGCCGATAGTGATTTCTTGCTTGAACGCGATGATGTTATTGAAGAAGGACGAGTTATTCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1X3JHM4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V0YCI1 |