Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3900760..3901417 Replicon chromosome
Accession NZ_CP090192
Organism Enterobacter hormaechei strain TUECL19003

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag LZU72_RS18690 Protein ID WP_022649305.1
Coordinates 3900760..3901170 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag LZU72_RS18695 Protein ID WP_003863437.1
Coordinates 3901151..3901417 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZU72_RS18670 (LZU72_18670) 3896758..3898491 - 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -
LZU72_RS18675 (LZU72_18675) 3898497..3899210 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LZU72_RS18680 (LZU72_18680) 3899239..3900135 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
LZU72_RS18685 (LZU72_18685) 3900237..3900758 + 522 WP_015571793.1 flavodoxin FldB -
LZU72_RS18690 (LZU72_18690) 3900760..3901170 - 411 WP_022649305.1 protein YgfX Toxin
LZU72_RS18695 (LZU72_18695) 3901151..3901417 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
LZU72_RS18700 (LZU72_18700) 3901712..3902692 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
LZU72_RS18705 (LZU72_18705) 3903216..3903875 - 660 WP_022649307.1 hemolysin III family protein -
LZU72_RS18710 (LZU72_18710) 3904142..3904873 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T230179 WP_022649305.1 NZ_CP090192:c3901170-3900760 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T230179 NZ_CP124743:120404-120709 [Escherichia coli O157:H7 str. EDL933]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT230179 WP_003863437.1 NZ_CP090192:c3901417-3901151 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT230179 NZ_CP124743:120184-120402 [Escherichia coli O157:H7 str. EDL933]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References