Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3633899..3634638 Replicon chromosome
Accession NZ_CP090192
Organism Enterobacter hormaechei strain TUECL19003

Toxin (Protein)


Gene name yeeV Uniprot ID A0A431SEP0
Locus tag LZU72_RS17410 Protein ID WP_022649088.1
Coordinates 3634258..3634638 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A431SER1
Locus tag LZU72_RS17405 Protein ID WP_022649087.1
Coordinates 3633899..3634225 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZU72_RS17390 (LZU72_17390) 3629793..3632453 - 2661 WP_022649084.1 antiviral RADAR system adenosine triphosphatase RdrA -
LZU72_RS17395 (LZU72_17395) 3633083..3633406 + 324 WP_022649085.1 antirestriction protein -
LZU72_RS17400 (LZU72_17400) 3633421..3633888 + 468 WP_022649086.1 DNA repair protein RadC -
LZU72_RS17405 (LZU72_17405) 3633899..3634225 + 327 WP_022649087.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LZU72_RS17410 (LZU72_17410) 3634258..3634638 + 381 WP_022649088.1 TA system toxin CbtA family protein Toxin
LZU72_RS17415 (LZU72_17415) 3634635..3634862 + 228 WP_022649089.1 DUF5983 family protein -
LZU72_RS17420 (LZU72_17420) 3635254..3635547 + 294 WP_022649090.1 contact-dependent growth inhibition system immunity protein -
LZU72_RS17425 (LZU72_17425) 3635891..3637207 - 1317 WP_022649091.1 amidase family protein -
LZU72_RS17430 (LZU72_17430) 3637262..3638557 - 1296 WP_022649092.1 histidinol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3610790..3635547 24757


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13850.66 Da        Isoelectric Point: 5.8788

>T230178 WP_022649088.1 NZ_CP090192:3634258-3634638 [Enterobacter hormaechei]
MQTLPLPEPRAAEPCPSPVQVWQLLLTHLLDKHYGLTLNDTPFGDDGVIQAHINAGISLCDAVNFIVERYELLRTDHSSS
SLTEHSSLIGAIDILRAHRATGLIVGSGYSTITRITTGQYREDKTQ

Download         Length: 381 bp

>T230178 NZ_CP124743:73386-73661 [Escherichia coli O157:H7 str. EDL933]
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11923.47 Da        Isoelectric Point: 5.8762

>AT230178 WP_022649087.1 NZ_CP090192:3633899-3634225 [Enterobacter hormaechei]
MHSEQWGLTCGKTPCFSAKLVQEGNRLHFLADRAEFSGDLSDDEALRLDQAFPVILKQLEQMLSAGELNPRHQHRVTLHL
NGLTCEADTLGSHGYLYIAIYPSAVATG

Download         Length: 327 bp

>AT230178 NZ_CP124743:73102-73386 [Escherichia coli O157:H7 str. EDL933]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SEP0

Antitoxin

Source ID Structure
AlphaFold DB A0A431SER1

References