Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2293303..2294042 Replicon chromosome
Accession NZ_CP090192
Organism Enterobacter hormaechei strain TUECL19003

Toxin (Protein)


Gene name tacT Uniprot ID A0A3S0FZ61
Locus tag LZU72_RS11090 Protein ID WP_022648141.1
Coordinates 2293303..2293788 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag LZU72_RS11095 Protein ID WP_003857131.1
Coordinates 2293776..2294042 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZU72_RS11065 (LZU72_11065) 2289459..2290481 + 1023 WP_022648135.1 alpha/beta hydrolase -
LZU72_RS11070 (LZU72_11070) 2290577..2291341 + 765 WP_022648136.1 SDR family oxidoreductase -
LZU72_RS11075 (LZU72_11075) 2292008..2292271 + 264 WP_022648138.1 DUF4225 domain-containing protein -
LZU72_RS11080 (LZU72_11080) 2292246..2292575 - 330 WP_022648139.1 hypothetical protein -
LZU72_RS11085 (LZU72_11085) 2292708..2293277 + 570 WP_022648140.1 hypothetical protein -
LZU72_RS11090 (LZU72_11090) 2293303..2293788 - 486 WP_022648141.1 GNAT family N-acetyltransferase Toxin
LZU72_RS11095 (LZU72_11095) 2293776..2294042 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
LZU72_RS11100 (LZU72_11100) 2294106..2295035 - 930 WP_022648142.1 LysR family transcriptional regulator -
LZU72_RS11105 (LZU72_11105) 2295165..2296553 + 1389 WP_022648143.1 MFS transporter -
LZU72_RS11110 (LZU72_11110) 2296532..2297089 - 558 WP_022648144.1 OmpH family outer membrane protein -
LZU72_RS11115 (LZU72_11115) 2297210..2298346 - 1137 WP_022648145.1 type 1 fimbrial protein -
LZU72_RS11120 (LZU72_11120) 2298370..2298948 - 579 WP_022648146.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2270436..2294042 23606


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.24 Da        Isoelectric Point: 9.6275

>T230169 WP_022648141.1 NZ_CP090192:c2293788-2293303 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFISGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T230169 NZ_CP124740:c3112486-3112001 [Escherichia coli O157:H7 str. EDL933]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCGTTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACGTAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT230169 WP_003857131.1 NZ_CP090192:c2294042-2293776 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT230169 NZ_CP124740:c3112755-3112477 [Escherichia coli O157:H7 str. EDL933]
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGAGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCCTTGATGACGAGCAATACGATGCGTTTCTCGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGCCAAA
ATTAACGCGTTGATGAATCGTAAATCGCCATGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0FZ61

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References