Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1097986..1098607 Replicon chromosome
Accession NZ_CP090192
Organism Enterobacter hormaechei strain TUECL19003

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag LZU72_RS05215 Protein ID WP_015571250.1
Coordinates 1097986..1098204 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag LZU72_RS05220 Protein ID WP_006809850.1
Coordinates 1098233..1098607 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZU72_RS05185 (LZU72_05185) 1093998..1094258 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
LZU72_RS05190 (LZU72_05190) 1094261..1094401 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LZU72_RS05195 (LZU72_05195) 1094398..1095108 - 711 WP_022647267.1 GNAT family protein -
LZU72_RS05200 (LZU72_05200) 1095211..1096671 + 1461 WP_022647268.1 PLP-dependent aminotransferase family protein -
LZU72_RS05205 (LZU72_05205) 1096643..1097110 - 468 WP_022647269.1 YlaC family protein -
LZU72_RS05210 (LZU72_05210) 1097227..1097778 - 552 WP_022647270.1 maltose O-acetyltransferase -
LZU72_RS05215 (LZU72_05215) 1097986..1098204 - 219 WP_015571250.1 HHA domain-containing protein Toxin
LZU72_RS05220 (LZU72_05220) 1098233..1098607 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
LZU72_RS05225 (LZU72_05225) 1099117..1102263 - 3147 WP_022647271.1 multidrug efflux RND transporter permease subunit AcrB -
LZU72_RS05230 (LZU72_05230) 1102286..1103479 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T230168 WP_015571250.1 NZ_CP090192:c1098204-1097986 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T230168 NZ_CP124740:3063344-3063871 [Escherichia coli O157:H7 str. EDL933]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAACGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATAAATCGCTGGGCTTTATCCCTTTAGTCGGGGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT230168 WP_006809850.1 NZ_CP090192:c1098607-1098233 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT230168 NZ_CP124740:3063071-3063337 [Escherichia coli O157:H7 str. EDL933]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References