Detailed information of TA system TA230162

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 615460..616019
• Replicon: chromosome
• Accession: NZ_CP090179
• Organism: Vibrio harveyi strain XH2145

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LXG94_RS13410
• Protein ID: WP_038899484.1
• Coordinates: 615460..615738 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A347UR21
• Locus tag: LXG94_RS13415
• Protein ID: WP_005398409.1
• Coordinates: 615735..616019 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXG94_RS13345 (LXG94_13345)	610981..611181	+	201	WP_038899642.1	hypothetical protein	-
LXG94_RS13350 (LXG94_13350)	611199..611288	+	90	WP_078554837.1	DUF3265 domain-containing protein	-
LXG94_RS13355 (LXG94_13355)	611360..611869	-	510	WP_038899643.1	hypothetical protein	-
LXG94_RS13360 (LXG94_13360)	611866..613029	-	1164	WP_080640441.1	PAAR domain-containing protein	-
LXG94_RS13365 (LXG94_13365)	613267..613608	+	342	WP_017191348.1	hypothetical protein	-
LXG94_RS13370 (LXG94_13370)	613644..613736	+	93	WP_080637453.1	DUF3265 domain-containing protein	-
LXG94_RS13375 (LXG94_13375)	613763..614287	+	525	WP_227740487.1	hypothetical protein	-
LXG94_RS13380 (LXG94_13380)	614302..614394	+	93	WP_080640453.1	DUF3265 domain-containing protein	-
LXG94_RS13385 (LXG94_13385)	614421..614828	+	408	WP_038899727.1	DUF1330 domain-containing protein	-
LXG94_RS13390 (LXG94_13390)	614855..614947	+	93	WP_193788553.1	DUF3265 domain-containing protein	-
LXG94_RS13395 (LXG94_13395)	614977..615303	+	327	WP_038899725.1	hypothetical protein	-
LXG94_RS13400 (LXG94_13400)	615300..615377	+	78	Protein_713	DUF3265 domain-containing protein	-
LXG94_RS13405 (LXG94_13405)	615353..615431	+	79	Protein_714	DUF3265 domain-containing protein	-
LXG94_RS13410 (LXG94_13410)	615460..615738	-	279	WP_038899484.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
LXG94_RS13415 (LXG94_13415)	615735..616019	-	285	WP_005398409.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LXG94_RS13420 (LXG94_13420)	616096..616186	+	91	Protein_717	DUF3265 domain-containing protein	-
LXG94_RS13425 (LXG94_13425)	616676..616807	+	132	WP_080990692.1	DUF3265 domain-containing protein	-
LXG94_RS13430 (LXG94_13430)	616962..617264	+	303	WP_038899751.1	BrnT family toxin	-
LXG94_RS13435 (LXG94_13435)	617266..617460	+	195	WP_038899752.1	hypothetical protein	-
LXG94_RS13440 (LXG94_13440)	617444..617599	+	156	WP_155397188.1	hypothetical protein	-
LXG94_RS13445 (LXG94_13445)	617623..617715	+	93	WP_072600976.1	DUF3265 domain-containing protein	-
LXG94_RS13450 (LXG94_13450)	617872..618309	+	438	WP_038899753.1	DUF5675 family protein	-
LXG94_RS13455 (LXG94_13455)	618313..618807	+	495	WP_050567850.1	hypothetical protein	-
LXG94_RS13460 (LXG94_13460)	618911..619558	+	648	WP_038899754.1	HNH endonuclease	-
LXG94_RS13470 (LXG94_13470)	619754..620413	+	660	WP_050567852.1	hypothetical protein	-
LXG94_RS13475 (LXG94_13475)	620436..620528	+	93	WP_193788555.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	509766..632527	122761
	-	inside	Integron	-	-	508515..626933	118418

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-69)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 11038.75 Da
• Isoelectric Point: 4.4558

>T230162 WP_038899484.1 NZ_CP090179:c615738-615460 [Vibrio harveyi]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRRRLLIIPEISMIVSYWFEGDIIRVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T230162 NZ_CP124740:c1865985-1865671 [Escherichia coli O157:H7 str. EDL933]
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11069.40 Da
• Isoelectric Point: 9.2167

>AT230162 WP_005398409.1 NZ_CP090179:c616019-615735 [Vibrio harveyi]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT230162 NZ_CP124740:c1866221-1865988 [Escherichia coli O157:H7 str. EDL933]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Structures

Antitoxin

• AlphaFold DB: A0A347UR21