Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 590417..590945 Replicon chromosome
Accession NZ_CP090179
Organism Vibrio harveyi strain XH2145

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag LXG94_RS13110 Protein ID WP_005377002.1
Coordinates 590417..590707 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag LXG94_RS13115 Protein ID WP_005377003.1
Coordinates 590697..590945 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXG94_RS13060 (LXG94_13060) 586240..586674 + 435 WP_038899378.1 GNAT family N-acetyltransferase -
LXG94_RS13065 (LXG94_13065) 586692..586781 + 90 WP_072833189.1 DUF3265 domain-containing protein -
LXG94_RS13070 (LXG94_13070) 587159..587248 + 90 WP_072615037.1 DUF3265 domain-containing protein -
LXG94_RS13075 (LXG94_13075) 587276..587515 + 240 WP_009696107.1 hypothetical protein -
LXG94_RS13080 (LXG94_13080) 587621..587714 + 94 Protein_649 DUF3265 domain-containing protein -
LXG94_RS13085 (LXG94_13085) 587741..588511 + 771 WP_038899379.1 hypothetical protein -
LXG94_RS13090 (LXG94_13090) 588648..589265 + 618 WP_053051972.1 LysE family translocator -
LXG94_RS13095 (LXG94_13095) 589286..589378 + 93 WP_080338851.1 DUF3265 domain-containing protein -
LXG94_RS13100 (LXG94_13100) 589461..589763 + 303 WP_038899491.1 hypothetical protein -
LXG94_RS13105 (LXG94_13105) 589753..590283 + 531 WP_038899490.1 hypothetical protein -
LXG94_RS13110 (LXG94_13110) 590417..590707 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXG94_RS13115 (LXG94_13115) 590697..590945 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LXG94_RS13120 (LXG94_13120) 591020..591088 + 69 WP_140201510.1 DUF3265 domain-containing protein -
LXG94_RS13125 (LXG94_13125) 591212..591514 - 303 WP_038899489.1 hypothetical protein -
LXG94_RS13130 (LXG94_13130) 591643..591732 + 90 WP_079764169.1 DUF3265 domain-containing protein -
LXG94_RS13135 (LXG94_13135) 591765..592475 + 711 WP_038899488.1 hypothetical protein -
LXG94_RS13140 (LXG94_13140) 592592..593188 + 597 WP_050567839.1 hypothetical protein -
LXG94_RS13145 (LXG94_13145) 593206..593295 + 90 WP_227740479.1 DUF3265 domain-containing protein -
LXG94_RS13150 (LXG94_13150) 593324..593977 + 654 WP_038899487.1 hypothetical protein -
LXG94_RS13155 (LXG94_13155) 593984..594073 + 90 WP_193788544.1 DUF3265 domain-containing protein -
LXG94_RS13160 (LXG94_13160) 594492..594621 + 130 Protein_665 DUF3265 domain-containing protein -
LXG94_RS13165 (LXG94_13165) 594650..595423 + 774 WP_038899589.1 NERD domain-containing protein -
LXG94_RS13170 (LXG94_13170) 595438..595530 + 93 WP_080346573.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 509766..632527 122761
- inside Integron - - 508515..626933 118418


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T230161 WP_005377002.1 NZ_CP090179:c590707-590417 [Vibrio harveyi]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T230161 NZ_CP124740:c1630836-1630438 [Escherichia coli O157:H7 str. EDL933]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAGCTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACTTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAATCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT230161 WP_005377003.1 NZ_CP090179:c590945-590697 [Vibrio harveyi]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT230161 NZ_CP124740:c1631132-1630839 [Escherichia coli O157:H7 str. EDL933]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAATTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References