Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3993745..3994526 Replicon chromosome
Accession NZ_CP090146
Organism Enterobacter hormaechei strain TUECL19001

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A431SHU0
Locus tag LXD76_RS19175 Protein ID WP_022649378.1
Coordinates 3993745..3994236 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3S0FY21
Locus tag LXD76_RS19180 Protein ID WP_022649379.1
Coordinates 3994233..3994526 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXD76_RS19160 (LXD76_19160) 3989025..3989477 - 453 WP_022649375.1 hypothetical protein -
LXD76_RS19165 (LXD76_19165) 3989992..3991902 + 1911 WP_022649376.1 hypothetical protein -
LXD76_RS19170 (LXD76_19170) 3991899..3993593 + 1695 WP_022649377.1 hypothetical protein -
LXD76_RS19175 (LXD76_19175) 3993745..3994236 - 492 WP_022649378.1 GNAT family N-acetyltransferase Toxin
LXD76_RS19180 (LXD76_19180) 3994233..3994526 - 294 WP_022649379.1 DUF1778 domain-containing protein Antitoxin
LXD76_RS19185 (LXD76_19185) 3994628..3996421 - 1794 WP_022649380.1 hybrid sensor histidine kinase/response regulator -
LXD76_RS19190 (LXD76_19190) 3996418..3997050 - 633 WP_022649381.1 response regulator transcription factor -
LXD76_RS19195 (LXD76_19195) 3997226..3997540 + 315 WP_003862457.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(83-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17469.36 Da        Isoelectric Point: 8.1405

>T230151 WP_022649378.1 NZ_CP090146:c3994236-3993745 [Enterobacter hormaechei]
MISAPVPLRAGHILTPFCCGVDSMDNWLKQRAMKNQASGASRTFVCCGGDSNVLAYYALASSAVTTNTVPGRFRRNMPDP
IPVVVLGRLAVDQSLHGQGVGRALVRDAGLRVIQVAESIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMILMVTLGDLV
ASI

Download         Length: 492 bp

>T230151 NZ_CP124733:2401389-2401535 [Agrobacterium larrymoorei]
ATTTCCGAAGGAAGCGGCTCGCGTGTTCGGGTTGCACTCAACGGGATGCGAGCGGTGTTTCACCGTCCGCATCCGCAAAA
AGAAACGGACAAGGGAGCAGTGAAATCGGTGCGCCGGTTTCTTAGCGAAGCAGGAATAAGACCATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10959.58 Da        Isoelectric Point: 8.6351

>AT230151 WP_022649379.1 NZ_CP090146:c3994526-3994233 [Enterobacter hormaechei]
MPAANTMAVKRETLNLRIRPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLTRLDQAPAPN
AALRKTMQTLAPWEQEK

Download         Length: 294 bp

>AT230151 NZ_CP124733:2401532-2401861 [Agrobacterium larrymoorei]
ATGACCTTGATGCATTACAAGGGCTATGAAGCGGTCATCGAGTTCGATGAGGATGCAGAGATTTTCCACGGTGAAGTCAT
CAATCTGCGCGACGTGATTACGTTTCAGGGCTCATCCGCAGCGGAGCTGAAACAGGCTTTGGCCGAATCTGTCGAAGACT
ATATCTCCTTCTGCAAGGAACGTGGGGAAGAACCGGAAAAGCCATTTTCCGGCCAGTTCGTCGTGCGCGCTGAGCCGCGC
CTGCATAAGGCGATTTCTACGGCTGCCCGAAGAGACGGCGTGAGCCTCAATAAGTGGGTGACATCGACGCTGGAAAAGGC
CGTCTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SHU0

Antitoxin

Source ID Structure
AlphaFold DB A0A3S0FY21

References