Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3900807..3901464 Replicon chromosome
Accession NZ_CP090146
Organism Enterobacter hormaechei strain TUECL19001

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag LXD76_RS18700 Protein ID WP_022649305.1
Coordinates 3900807..3901217 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag LXD76_RS18705 Protein ID WP_003863437.1
Coordinates 3901198..3901464 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXD76_RS18680 (LXD76_18680) 3896805..3898538 - 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -
LXD76_RS18685 (LXD76_18685) 3898544..3899257 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LXD76_RS18690 (LXD76_18690) 3899286..3900182 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
LXD76_RS18695 (LXD76_18695) 3900284..3900805 + 522 WP_015571793.1 flavodoxin FldB -
LXD76_RS18700 (LXD76_18700) 3900807..3901217 - 411 WP_022649305.1 protein YgfX Toxin
LXD76_RS18705 (LXD76_18705) 3901198..3901464 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
LXD76_RS18710 (LXD76_18710) 3901759..3902739 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
LXD76_RS18715 (LXD76_18715) 3903263..3903922 - 660 WP_022649307.1 hemolysin III family protein -
LXD76_RS18720 (LXD76_18720) 3904189..3904920 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T230150 WP_022649305.1 NZ_CP090146:c3901217-3900807 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T230150 NZ_CP124733:c2359210-2358983 [Agrobacterium larrymoorei]
ATGAATCCGGTCGTTACGACATGGTGGCTAAAGGAAGTAATGCTTCTCTCCATCGCCAACGACGCGCCGTTACCTCTTAA
TTTTCGTGATCATGAACTTACGGGTGACTGGCGGGACCACCGGGAATGCCATATCGGCGGAGATTTCCTGTTGATCTACA
CCTTGGACGACGCCCAGAATCTCATCGTCTTCACGCGCGCAGGAACACACTCGGAGTTGTTCAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT230150 WP_003863437.1 NZ_CP090146:c3901464-3901198 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT230150 NZ_CP124733:c2359588-2359313 [Agrobacterium larrymoorei]
ATGACTGCCAATGCCTATGTGAGGGCTCGGATAGATCAGGAAATTAAAGATGATGCGACCGCTGTTCTGGACAGTTTGGG
GCTTACGGTTTCCGATGTGATGCGCATGATGCTGACACGTATTGCCAGAGAAAAAGCTCTTCCCATCGAACTGACCAGAC
CAAACGCAGAAACGCTGGCTGCCCTGGAAGAGGCCAAAGAAATCGCGCGCGCAAAACGCGAACGCTTTCGTTCGGCAGAA
GAACTTTTTGACGCTCTCAATGGCGGTAAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References