Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3633946..3634685 Replicon chromosome
Accession NZ_CP090146
Organism Enterobacter hormaechei strain TUECL19001

Toxin (Protein)


Gene name yeeV Uniprot ID A0A431SEP0
Locus tag LXD76_RS17420 Protein ID WP_022649088.1
Coordinates 3634305..3634685 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A431SER1
Locus tag LXD76_RS17415 Protein ID WP_022649087.1
Coordinates 3633946..3634272 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXD76_RS17400 (LXD76_17400) 3629840..3632500 - 2661 WP_022649084.1 antiviral RADAR system adenosine triphosphatase RdrA -
LXD76_RS17405 (LXD76_17405) 3633130..3633453 + 324 WP_022649085.1 antirestriction protein -
LXD76_RS17410 (LXD76_17410) 3633468..3633935 + 468 WP_022649086.1 DNA repair protein RadC -
LXD76_RS17415 (LXD76_17415) 3633946..3634272 + 327 WP_022649087.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LXD76_RS17420 (LXD76_17420) 3634305..3634685 + 381 WP_022649088.1 TA system toxin CbtA family protein Toxin
LXD76_RS17425 (LXD76_17425) 3634682..3634909 + 228 WP_022649089.1 DUF5983 family protein -
LXD76_RS17430 (LXD76_17430) 3635301..3635594 + 294 WP_022649090.1 contact-dependent growth inhibition system immunity protein -
LXD76_RS17435 (LXD76_17435) 3635938..3637254 - 1317 WP_022649091.1 amidase family protein -
LXD76_RS17440 (LXD76_17440) 3637309..3638604 - 1296 WP_022649092.1 histidinol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3610837..3635594 24757


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13850.66 Da        Isoelectric Point: 5.8788

>T230149 WP_022649088.1 NZ_CP090146:3634305-3634685 [Enterobacter hormaechei]
MQTLPLPEPRAAEPCPSPVQVWQLLLTHLLDKHYGLTLNDTPFGDDGVIQAHINAGISLCDAVNFIVERYELLRTDHSSS
SLTEHSSLIGAIDILRAHRATGLIVGSGYSTITRITTGQYREDKTQ

Download         Length: 381 bp

>T230149 NZ_CP124733:2284770-2285066 [Agrobacterium larrymoorei]
ATGGAAAAATCTGCGCCTCATACTGCGCTCGAAGATGTATGGCGATTATTGGATGAAGGCAAAGTCAGGGAAACATTCTC
AGCCTTGGGCGGAGCCGCGGCTCTCGGCATGTCGCGGAGTGATATGCATGACGTCGTGCGCGCCTTAAGCCGCAAGGATT
TCTTCAAATCCATGACGGCTTACCACGACGAGACCATCTGGCATGATGTCTATAAACCGGTGACGCCCTTCGGGCACCTG
TATGTAAAACTGATCGTATCGAACAACGTGCTGATCGTGTCGTTCAAGGAGAAGTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11923.47 Da        Isoelectric Point: 5.8762

>AT230149 WP_022649087.1 NZ_CP090146:3633946-3634272 [Enterobacter hormaechei]
MHSEQWGLTCGKTPCFSAKLVQEGNRLHFLADRAEFSGDLSDDEALRLDQAFPVILKQLEQMLSAGELNPRHQHRVTLHL
NGLTCEADTLGSHGYLYIAIYPSAVATG

Download         Length: 327 bp

>AT230149 NZ_CP124733:2285068-2285469 [Agrobacterium larrymoorei]
ATGGCTTGCCCTATTTGCGGCGCTGATGCCGTGACGAAGGAAACGCGCGATCTTGAATATTCCTACAAAGGACAAGTCAC
GGTTATTCCTCATGTGACGGGCACATTTTGCAGCGCTTGCGGCGAAGCCATACTGGAAGGCGAAGAGAGCGAACGCGTGA
GTGCCGCGATGCTCGCTTTCAACAGAGAGGTCAATGCGAGCTTTGTCGATCCCGAATACATCGCCAAGGTTCGCAAAAAG
CTTTCGCTGGACCAGCGGGAAGCAGGCGATCTTTTCGGCGGTGGCGTGAATGCCTTCTCGCGTTACGAGAACGGTAAATC
ACGCCCGCCGCGCTCGCTTATCCAGTTGCTCAAGATATTGGAGAAGCACCCCGACCTGCTGGACGAAATCAAGGCTGCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SEP0

Antitoxin

Source ID Structure
AlphaFold DB A0A431SER1

References