Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2293350..2294089 Replicon chromosome
Accession NZ_CP090146
Organism Enterobacter hormaechei strain TUECL19001

Toxin (Protein)


Gene name tacT Uniprot ID A0A3S0FZ61
Locus tag LXD76_RS11090 Protein ID WP_022648141.1
Coordinates 2293350..2293835 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag LXD76_RS11095 Protein ID WP_003857131.1
Coordinates 2293823..2294089 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXD76_RS11065 (LXD76_11065) 2289506..2290528 + 1023 WP_022648135.1 alpha/beta hydrolase -
LXD76_RS11070 (LXD76_11070) 2290624..2291388 + 765 WP_022648136.1 SDR family oxidoreductase -
LXD76_RS11075 (LXD76_11075) 2292055..2292318 + 264 WP_022648138.1 DUF4225 domain-containing protein -
LXD76_RS11080 (LXD76_11080) 2292293..2292622 - 330 WP_022648139.1 hypothetical protein -
LXD76_RS11085 (LXD76_11085) 2292755..2293324 + 570 WP_022648140.1 hypothetical protein -
LXD76_RS11090 (LXD76_11090) 2293350..2293835 - 486 WP_022648141.1 GNAT family N-acetyltransferase Toxin
LXD76_RS11095 (LXD76_11095) 2293823..2294089 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
LXD76_RS11100 (LXD76_11100) 2294153..2295082 - 930 WP_022648142.1 LysR family transcriptional regulator -
LXD76_RS11105 (LXD76_11105) 2295212..2296600 + 1389 WP_022648143.1 MFS transporter -
LXD76_RS11110 (LXD76_11110) 2296579..2297136 - 558 WP_022648144.1 OmpH family outer membrane protein -
LXD76_RS11115 (LXD76_11115) 2297257..2298393 - 1137 WP_022648145.1 type 1 fimbrial protein -
LXD76_RS11120 (LXD76_11120) 2298417..2298995 - 579 WP_022648146.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2270483..2294089 23606


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.24 Da        Isoelectric Point: 9.6275

>T230140 WP_022648141.1 NZ_CP090146:c2293835-2293350 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFISGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T230140 NZ_CP124733:c712142-711741 [Agrobacterium larrymoorei]
ATGCGGTATCTTCTCGATACGAACGCCATCTCCCACGTCATAGATTTCCCGACGGGATCTGTGGCTCAGAGAATAAGGAC
AGAAGCAGTTACAGGAACATTGGTCACGAGTGTCATCGTGGTTGCCGAGTTGCGATATGGCTACACGAAGATTTCGTCTC
AGCGGTTGAGAGACGCGTACGAAACGTTTTTTGAAAGCCTGCCCATCGAAAACTGGGAGGCACCGTTTGATCACGTTTAT
GCGGACATTCGGGATCAGTTGACGAAGAAGGGCCGGTCGATTGGCGCGATGGACATGCTGATTGCAGCCCACGCCTTGGC
AACCGATGCGGTGGTGGTCACCGCAAATATAAAGCACTTTTCAGAAGTGCCGGAACTGAAAGTTGAAAATTGGCTTCGAT
AG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT230140 WP_003857131.1 NZ_CP090146:c2294089-2293823 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT230140 NZ_CP124733:c712405-712142 [Agrobacterium larrymoorei]
ATGGTAGCAGTCATCGAAAAAGAGGTCAGCGTTTTCAACAATGGGCGCAGTCGGGCCGTGCGCATACCGTCCGACTTCAA
GCTCGAGGGTGACAGCGTTCTCATGTCTCAGGATGAAGACGGCGTGATCCATATTCGCCCTAAGAAGCCGAAGAAGTCGC
TGCTTGAGGTGCTGGATTGGTTGGCAAAGCAGGAACCTTTTGAAGAGCGGATGCCGGAGATCGAGGACTATCCCCCTGAG
CCAGTGGACTTGGGCAAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0FZ61

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References