Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1098033..1098654 Replicon chromosome
Accession NZ_CP090146
Organism Enterobacter hormaechei strain TUECL19001

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag LXD76_RS05215 Protein ID WP_015571250.1
Coordinates 1098033..1098251 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag LXD76_RS05220 Protein ID WP_006809850.1
Coordinates 1098280..1098654 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXD76_RS05185 (LXD76_05185) 1094045..1094305 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
LXD76_RS05190 (LXD76_05190) 1094308..1094448 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LXD76_RS05195 (LXD76_05195) 1094445..1095155 - 711 WP_022647267.1 GNAT family protein -
LXD76_RS05200 (LXD76_05200) 1095258..1096718 + 1461 WP_022647268.1 PLP-dependent aminotransferase family protein -
LXD76_RS05205 (LXD76_05205) 1096690..1097157 - 468 WP_022647269.1 YlaC family protein -
LXD76_RS05210 (LXD76_05210) 1097274..1097825 - 552 WP_022647270.1 maltose O-acetyltransferase -
LXD76_RS05215 (LXD76_05215) 1098033..1098251 - 219 WP_015571250.1 HHA domain-containing protein Toxin
LXD76_RS05220 (LXD76_05220) 1098280..1098654 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
LXD76_RS05225 (LXD76_05225) 1099164..1102310 - 3147 WP_022647271.1 multidrug efflux RND transporter permease subunit AcrB -
LXD76_RS05230 (LXD76_05230) 1102333..1103526 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T230139 WP_015571250.1 NZ_CP090146:c1098251-1098033 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T230139 NZ_CP124733:c327380-327219 [Agrobacterium larrymoorei]
ATGAAGAGCACTGATATTATAGCGGCACTTCGCAAGGGCAGTCATGTCCAGTTCAAGCATGCTTCGAAACCCGGACGTGT
CACCGTCCCGCATCCCAAGAGAGACTTGCCCATCGGTACGCTTAAAAGCATAGAGAAGCAGGCCGGGTTGAAACTGAGGT
AG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT230139 WP_006809850.1 NZ_CP090146:c1098654-1098280 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT230139 NZ_CP124733:c327214-326813 [Agrobacterium larrymoorei]
ATGCGGAATTACATCGGACTGATCCACAAGCACGCTGATAGCGATTACGGAGTATCGTTCCCCGACTTCCCAGGCGTCGT
GACTGCTGGAACGGATTTGGATGACGCACGTCTGATGGCCGAGGAAGCGCTATCCCTTCATGTCGAGGGGCTGCTGGAAG
ATGGCGACGCCATTCCCGAGCCATCGAGTCTGGATGACGTTATGAAAGATGGCGAAAACAAAATGGCTGTCGCAATCCTC
GTTTCGCTGAAGTCCGAGAGCAAGAGAGCCGTTCGCCTTAACATCACCTTGCCTGAAGACGTTCTGCGGGACATCGATGC
TTACGCACAAGCGCACGGATTGACCCGTTCGGGCTTCCTGGCGCGCGCCGCGAAACACGAAATCTCCTCTGCGAGTGCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References