Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 91121..92744 Replicon plasmid p5ASAL09_294k
Accession NZ_CP090142
Organism Salmonella enterica subsp. enterica serovar Goldcoast strain 5ASAL09

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag LZK30_RS22675 Protein ID WP_000088046.1
Coordinates 91419..92744 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag LZK30_RS22670 Protein ID WP_024136327.1
Coordinates 91121..91414 (+) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZK30_RS22640 (LZK30_22640) 86663..86944 - 282 WP_000077926.1 hypothetical protein -
LZK30_RS22645 (LZK30_22645) 86994..87185 - 192 WP_000398480.1 hypothetical protein -
LZK30_RS22650 (LZK30_22650) 87409..88581 + 1173 WP_000952349.1 IS21-like element IS21 family transposase -
LZK30_RS22655 (LZK30_22655) 88581..89378 + 798 WP_000544828.1 IS21-like element IS21 family helper ATPase IstB -
LZK30_RS22660 (LZK30_22660) 89417..89752 - 336 WP_065311125.1 hypothetical protein -
LZK30_RS22665 (LZK30_22665) 90125..90517 + 393 WP_000341066.1 hypothetical protein -
LZK30_RS22670 (LZK30_22670) 91121..91414 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
LZK30_RS22675 (LZK30_22675) 91419..92744 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
LZK30_RS22680 (LZK30_22680) 92805..93011 + 207 WP_000134171.1 hypothetical protein -
LZK30_RS22685 (LZK30_22685) 93113..93523 + 411 WP_000985911.1 hypothetical protein -
LZK30_RS22690 (LZK30_22690) 93536..94351 + 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
LZK30_RS22695 (LZK30_22695) 94605..95030 + 426 WP_001043843.1 hypothetical protein -
LZK30_RS22700 (LZK30_22700) 95579..95887 + 309 WP_001224687.1 hypothetical protein -
LZK30_RS22705 (LZK30_22705) 95903..96760 + 858 WP_000784387.1 HNH endonuclease signature motif containing protein -
LZK30_RS22710 (LZK30_22710) 96822..97025 + 204 WP_001194555.1 hypothetical protein -
LZK30_RS22715 (LZK30_22715) 97367..97723 - 357 WP_065311124.1 H-NS family nucleoid-associated regulatory protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(3')-Ia / blaTEM-1B / blaLAP-2 / aac(3)-IId / aph(6)-Id / tet(A) / sul3 / lnu(F) / ant(3'')-Ia / sul2 / floR / blaCTX-M-55 / qnrS13 / ARR-3 / dfrA14 - 1..294023 294023


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(9-108)

Antitoxin

(21-69)


Sequences


Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T230137 WP_000088046.1 NZ_CP090142:91419-92744 [Salmonella enterica subsp. enterica serovar Goldcoast]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T230137 NZ_CP124732:c6784894-6784601 [Pseudomonas sp. GM17]
ATGAACGAACCGCTATTCGACTATGACCCCGCCACGGCCTTGCGCGACCCGCAAGCCATCGCCCTGTTCATGGCGGACGC
CTTCGAAACCGGCGATGCCGGCTATATCGCCAAAGCCCTGGGTGTGGTGGCGCGGGCCAAGGGCATGACTGAGCTGGCCC
ATGAAACCGGGCTGTCCCGCGAGCAGCTGTATCGCTCGTTCAGCGACAAGGGCAACCCGACCCTGAAGACCCTGCTGGCG
GTGATGCGTGCACTGGGGTTGGACATGACGGCGCGGGTGCATGGGGCGTCTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT230137 WP_024136327.1 NZ_CP090142:91121-91414 [Salmonella enterica subsp. enterica serovar Goldcoast]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT230137 NZ_CP124732:c6785190-6784891 [Pseudomonas sp. GM17]
ATGATCGAGATCAAACAGACCGCGACCTTTATGGAGTGGGAAAACAGGCTCAAGGATTCCAGAGCCAGGGCGTTGATTGC
TGCGCGGATTTTTCGCCTGGCCAACGGTCTTGCCGGGGACGTGTCCCCGGTGGGCGAAGGCGTCAGTGAGTTGCGCATCC
ATTACGGGCCGGGCTACCGGGTTTACTTCCAGCAGCGCGGCTTGCAACTCGTCATCCTGTTGTGCGGCGGCGACAAGAGT
CGCCAGAGCCGCGATATCGAACTGGCCAAATACCTGGCCCGTCGTTGGAGTCGATCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1


Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References