Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 91121..92744 | Replicon | plasmid p5ASAL09_294k |
Accession | NZ_CP090142 | ||
Organism | Salmonella enterica subsp. enterica serovar Goldcoast strain 5ASAL09 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | H9TH67 |
Locus tag | LZK30_RS22675 | Protein ID | WP_000088046.1 |
Coordinates | 91419..92744 (+) | Length | 442 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | A0A5Z6V2D1 |
Locus tag | LZK30_RS22670 | Protein ID | WP_024136327.1 |
Coordinates | 91121..91414 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LZK30_RS22640 (LZK30_22640) | 86663..86944 | - | 282 | WP_000077926.1 | hypothetical protein | - |
LZK30_RS22645 (LZK30_22645) | 86994..87185 | - | 192 | WP_000398480.1 | hypothetical protein | - |
LZK30_RS22650 (LZK30_22650) | 87409..88581 | + | 1173 | WP_000952349.1 | IS21-like element IS21 family transposase | - |
LZK30_RS22655 (LZK30_22655) | 88581..89378 | + | 798 | WP_000544828.1 | IS21-like element IS21 family helper ATPase IstB | - |
LZK30_RS22660 (LZK30_22660) | 89417..89752 | - | 336 | WP_065311125.1 | hypothetical protein | - |
LZK30_RS22665 (LZK30_22665) | 90125..90517 | + | 393 | WP_000341066.1 | hypothetical protein | - |
LZK30_RS22670 (LZK30_22670) | 91121..91414 | + | 294 | WP_024136327.1 | helix-turn-helix transcriptional regulator | Antitoxin |
LZK30_RS22675 (LZK30_22675) | 91419..92744 | + | 1326 | WP_000088046.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
LZK30_RS22680 (LZK30_22680) | 92805..93011 | + | 207 | WP_000134171.1 | hypothetical protein | - |
LZK30_RS22685 (LZK30_22685) | 93113..93523 | + | 411 | WP_000985911.1 | hypothetical protein | - |
LZK30_RS22690 (LZK30_22690) | 93536..94351 | + | 816 | WP_001572439.1 | HNH endonuclease signature motif containing protein | - |
LZK30_RS22695 (LZK30_22695) | 94605..95030 | + | 426 | WP_001043843.1 | hypothetical protein | - |
LZK30_RS22700 (LZK30_22700) | 95579..95887 | + | 309 | WP_001224687.1 | hypothetical protein | - |
LZK30_RS22705 (LZK30_22705) | 95903..96760 | + | 858 | WP_000784387.1 | HNH endonuclease signature motif containing protein | - |
LZK30_RS22710 (LZK30_22710) | 96822..97025 | + | 204 | WP_001194555.1 | hypothetical protein | - |
LZK30_RS22715 (LZK30_22715) | 97367..97723 | - | 357 | WP_065311124.1 | H-NS family nucleoid-associated regulatory protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | aph(3')-Ia / blaTEM-1B / blaLAP-2 / aac(3)-IId / aph(6)-Id / tet(A) / sul3 / lnu(F) / ant(3'')-Ia / sul2 / floR / blaCTX-M-55 / qnrS13 / ARR-3 / dfrA14 | - | 1..294023 | 294023 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 442 a.a. Molecular weight: 50249.20 Da Isoelectric Point: 6.1927
>T230137 WP_000088046.1 NZ_CP090142:91419-92744 [Salmonella enterica subsp. enterica serovar Goldcoast]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
Download Length: 1326 bp
>T230137 NZ_CP124732:c6784894-6784601 [Pseudomonas sp. GM17]
ATGAACGAACCGCTATTCGACTATGACCCCGCCACGGCCTTGCGCGACCCGCAAGCCATCGCCCTGTTCATGGCGGACGC
CTTCGAAACCGGCGATGCCGGCTATATCGCCAAAGCCCTGGGTGTGGTGGCGCGGGCCAAGGGCATGACTGAGCTGGCCC
ATGAAACCGGGCTGTCCCGCGAGCAGCTGTATCGCTCGTTCAGCGACAAGGGCAACCCGACCCTGAAGACCCTGCTGGCG
GTGATGCGTGCACTGGGGTTGGACATGACGGCGCGGGTGCATGGGGCGTCTTGA
ATGAACGAACCGCTATTCGACTATGACCCCGCCACGGCCTTGCGCGACCCGCAAGCCATCGCCCTGTTCATGGCGGACGC
CTTCGAAACCGGCGATGCCGGCTATATCGCCAAAGCCCTGGGTGTGGTGGCGCGGGCCAAGGGCATGACTGAGCTGGCCC
ATGAAACCGGGCTGTCCCGCGAGCAGCTGTATCGCTCGTTCAGCGACAAGGGCAACCCGACCCTGAAGACCCTGCTGGCG
GTGATGCGTGCACTGGGGTTGGACATGACGGCGCGGGTGCATGGGGCGTCTTGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10946.35 Da Isoelectric Point: 10.0925
>AT230137 WP_024136327.1 NZ_CP090142:91121-91414 [Salmonella enterica subsp. enterica serovar Goldcoast]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
Download Length: 294 bp
>AT230137 NZ_CP124732:c6785190-6784891 [Pseudomonas sp. GM17]
ATGATCGAGATCAAACAGACCGCGACCTTTATGGAGTGGGAAAACAGGCTCAAGGATTCCAGAGCCAGGGCGTTGATTGC
TGCGCGGATTTTTCGCCTGGCCAACGGTCTTGCCGGGGACGTGTCCCCGGTGGGCGAAGGCGTCAGTGAGTTGCGCATCC
ATTACGGGCCGGGCTACCGGGTTTACTTCCAGCAGCGCGGCTTGCAACTCGTCATCCTGTTGTGCGGCGGCGACAAGAGT
CGCCAGAGCCGCGATATCGAACTGGCCAAATACCTGGCCCGTCGTTGGAGTCGATCATGA
ATGATCGAGATCAAACAGACCGCGACCTTTATGGAGTGGGAAAACAGGCTCAAGGATTCCAGAGCCAGGGCGTTGATTGC
TGCGCGGATTTTTCGCCTGGCCAACGGTCTTGCCGGGGACGTGTCCCCGGTGGGCGAAGGCGTCAGTGAGTTGCGCATCC
ATTACGGGCCGGGCTACCGGGTTTACTTCCAGCAGCGCGGCTTGCAACTCGTCATCCTGTTGTGCGGCGGCGACAAGAGT
CGCCAGAGCCGCGATATCGAACTGGCCAAATACCTGGCCCGTCGTTGGAGTCGATCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3T0VBU1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5Z6V2D1 |