Detailed information of TA system TA230134

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4000300..4000816
• Replicon: chromosome
• Accession: NZ_CP090141
• Organism: Salmonella enterica subsp. enterica serovar Goldcoast strain 5ASAL09

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LZK30_RS19150
• Protein ID: WP_133323120.1
• Coordinates: 4000300..4000584 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V7ISI8
• Locus tag: LZK30_RS19155
• Protein ID: WP_000212724.1
• Coordinates: 4000574..4000816 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZK30_RS19135 (3995512)	3995512..3997164	+	1653	WP_023137597.1	alpha,alpha-phosphotrehalase	-
LZK30_RS19140 (3997573)	3997573..3999711	+	2139	WP_000187818.1	anaerobic ribonucleoside-triphosphate reductase	-
LZK30_RS19145 (3999832)	3999832..4000296	+	465	WP_133323118.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
LZK30_RS19150 (4000300)	4000300..4000584	-	285	WP_133323120.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LZK30_RS19155 (4000574)	4000574..4000816	-	243	WP_000212724.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LZK30_RS19160 (4000894)	4000894..4002807	-	1914	WP_001212140.1	BglG family transcription antiterminator	-
LZK30_RS19165 (4002824)	4002824..4003564	-	741	WP_023229489.1	KDGP aldolase family protein	-
LZK30_RS19170 (4003561)	4003561..4004679	-	1119	WP_133323122.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
LZK30_RS19175 (4004663)	4004663..4005796	-	1134	WP_133323124.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10926.73 Da
• Isoelectric Point: 9.8739

>T230134 WP_133323120.1 NZ_CP090141:c4000584-4000300 [Salmonella enterica subsp. enterica serovar Goldcoast]
MTYELEFDPRALKEWHKLDDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T230134 NZ_CP124732:4406054-4406236 [Pseudomonas sp. GM17]
GTGCAAAGCAGACAGTTGATCAAGGAGCTTGAAGCCGCAGGCTGGGTGCTGGAGCGCGTCACCGGCAACCATCATCTGTT
CAAGCATCCCTACCGGCCCGAGACCGTTCCGGTGCCGCACCCGAAGAAGGATCTGCCACGGGGGACGGTCAGGGCCATCA
AGAAACTGGCCGGGCTGATATAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT230134 WP_000212724.1 NZ_CP090141:c4000816-4000574 [Salmonella enterica subsp. enterica serovar Goldcoast]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT230134 NZ_CP124732:4406272-4406673 [Pseudomonas sp. GM17]
GTGCAATATCCCATCTGCATAGAGTGGGGCGACGAGCACACGGCTACCGGCATCCAGATTCCCGACATTCCTGGCGCGGT
AACCGCCGGCGACACCTTCGAGGCCGCGTATAGCGCCGCCATCGAGATCGCCCACGTCATGCTCGAAGAACTGGCCCGTG
AGGGACAAGCCATTCCCCTGCCCTCGCCCACCGGCACACACCGCGCCAACCCCGACTTCGAAGGGATGGGCTGGGGCATG
CTGGATATCGATATCACGCCTTACCTGGGCAAAACCGAGAAGGTCAATGTGACCCTGCCGGGCTACGTGATTCAACGCAT
CGACCGCTTTGTGCGCGAGCACAACATCAAGAGCCGGTCGTCTTTTCTCGCGGATGCGGCGATGGAAAAGCTGGGGCGTT
AA

Structures

Antitoxin

• AlphaFold DB: A0A5H5JRI5