Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3307322..3307942 Replicon chromosome
Accession NZ_CP090141
Organism Salmonella enterica subsp. enterica serovar Goldcoast strain 5ASAL09

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LZK30_RS15975 Protein ID WP_001280991.1
Coordinates 3307724..3307942 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LZK30_RS15970 Protein ID WP_000344807.1
Coordinates 3307322..3307696 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZK30_RS15960 (3302461) 3302461..3303654 + 1194 WP_126524221.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LZK30_RS15965 (3303677) 3303677..3306826 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LZK30_RS15970 (3307322) 3307322..3307696 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LZK30_RS15975 (3307724) 3307724..3307942 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LZK30_RS15980 (3308121) 3308121..3308672 + 552 WP_001278793.1 maltose O-acetyltransferase -
LZK30_RS15985 (3308788) 3308788..3309258 + 471 WP_000136183.1 YlaC family protein -
LZK30_RS15990 (3309314) 3309314..3309454 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LZK30_RS15995 (3309460) 3309460..3309720 - 261 WP_115276046.1 type B 50S ribosomal protein L31 -
LZK30_RS16000 (3309945) 3309945..3311495 + 1551 WP_000213138.1 EAL domain-containing protein -
LZK30_RS16010 (3311726) 3311726..3312115 + 390 WP_000961285.1 MGMT family protein -
LZK30_RS16015 (3312148) 3312148..3312717 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T230130 WP_001280991.1 NZ_CP090141:3307724-3307942 [Salmonella enterica subsp. enterica serovar Goldcoast]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T230130 NZ_CP124732:c1054402-1053974 [Pseudomonas sp. GM17]
ATGATCGTGCTCGACACCAATGTGCTGTCGGAACTGATGCGTCCCCAACCGGACGCATCGGTATTGCTGTGGATCGAAGC
GCAACCTGTCGAAGACCTCTACATCAGCGCCATGACCATGGCCGAGATTCTTCACGGCATCGCGCGCCTGCCCCACGGCA
AGCGCAAACAAATGCTCCATGCGTCGGCGCTGGCGATGTTCGAGGAAGATTTCATCGACCGCATCGTGCCCTTCGGGACC
CAGGCGGCTCTTTACTACGCCCATCTGATTTCGCACCGGGAAAGCCTGGGGCGTCCGATCAGCCTGGTGGATGCGCAAAT
TGCGGCCATATGCCGCGTCCACGACGCGGCTATCGCCACCCGTAACGCCAAGGACTTCAGCGACACCGGGTTGATCGTTA
TCAACCCCTGGCTGCCACTCGAAATCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT230130 WP_000344807.1 NZ_CP090141:3307322-3307696 [Salmonella enterica subsp. enterica serovar Goldcoast]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT230130 NZ_CP124732:c1054644-1054399 [Pseudomonas sp. GM17]
ATGGCCAGCCTGACAATCCGAAACCTGGACGACCACATCAAAGAGCGCCTGCGCATCGAGGCCGCTCACAACGGCCACTC
CATGGAAGAAGAAGCTCGCTTGATTTTGCGCCGCGCCCTGAGCAGAACAGCCGACAGCCAAGGCCTGGCCAGTCGTATCC
GGGCACGCTTTGCCGAGGCCGGCGGAGTGAAGCTTGAGCTGCCAGAACGTACCGAGCCGGCACGCGTGGTGGATCTGGGC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References