Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 14806..15332 Replicon plasmid pCVM19633_110
Accession NC_011092
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund str.

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag SESA_RS00080 Protein ID WP_000323025.1
Coordinates 15045..15332 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q5J3S4
Locus tag SESA_RS00075 Protein ID WP_000534857.1
Coordinates 14806..15045 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SESA_RS00055 9974..10933 + 960 WP_000208727.1 DUF523 and DUF1722 domain-containing protein -
SESA_RS00060 11079..12167 + 1089 WP_000633445.1 AAA family ATPase -
SESA_RS00065 12230..12934 - 705 WP_001067852.1 IS6-like element IS26 family transposase -
SESA_RS00070 13198..14271 - 1074 WP_000557466.1 hypothetical protein -
SESA_RS25540 14315..14464 - 150 WP_000550473.1 hypothetical protein -
SESA_RS00075 14806..15045 + 240 WP_000534857.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
SESA_RS00080 15045..15332 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
SESA_RS00085 15636..16418 - 783 WP_001531258.1 IS21-like element ISSen3 family helper ATPase IstB -
SESA_RS00090 16415..17437 - 1023 WP_000627495.1 IS21-like element ISSen3 family transposase -
SESA_RS23685 17576..17800 + 225 Protein_19 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..110227 110227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 12322.73 Da        Isoelectric Point: 12.7777

>T23012 WP_000323025.1 NC_011092:15045-15332 [Salmonella enterica subsp. enterica serovar Schwarzengrund str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKK

Download         Length: 288 bp

>T23012 NC_011092:15045-15332 [Salmonella enterica subsp. enterica serovar Schwarzengrund str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 10271.94 Da        Isoelectric Point: 12.6975

>AT23012 WP_000534857.1 NC_011092:14806-15045 [Salmonella enterica subsp. enterica serovar Schwarzengrund str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 240 bp

>AT23012 NC_011092:14806-15045 [Salmonella enterica subsp. enterica serovar Schwarzengrund str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A6C0NE60

References