Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4000190..4000706 Replicon chromosome
Accession NZ_CP090137
Organism Salmonella enterica subsp. enterica serovar Goldcoast strain 5ASAL05

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LZK31_RS19150 Protein ID WP_133323120.1
Coordinates 4000190..4000474 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LZK31_RS19155 Protein ID WP_000212724.1
Coordinates 4000464..4000706 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZK31_RS19135 (3995402) 3995402..3997054 + 1653 WP_023137597.1 alpha,alpha-phosphotrehalase -
LZK31_RS19140 (3997463) 3997463..3999601 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
LZK31_RS19145 (3999722) 3999722..4000186 + 465 WP_133323118.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LZK31_RS19150 (4000190) 4000190..4000474 - 285 WP_133323120.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZK31_RS19155 (4000464) 4000464..4000706 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LZK31_RS19160 (4000784) 4000784..4002697 - 1914 WP_001212140.1 BglG family transcription antiterminator -
LZK31_RS19165 (4002714) 4002714..4003454 - 741 WP_023229489.1 KDGP aldolase family protein -
LZK31_RS19170 (4003451) 4003451..4004569 - 1119 WP_133323122.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LZK31_RS19175 (4004553) 4004553..4005686 - 1134 WP_133323124.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10926.73 Da        Isoelectric Point: 9.8739

>T230114 WP_133323120.1 NZ_CP090137:c4000474-4000190 [Salmonella enterica subsp. enterica serovar Goldcoast]
MTYELEFDPRALKEWHKLDDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T230114 NZ_CP124702:1920049-1920151 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT230114 WP_000212724.1 NZ_CP090137:c4000706-4000464 [Salmonella enterica subsp. enterica serovar Goldcoast]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT230114 NZ_CP124702:c1920158-1920013 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References