Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 245026..246649 Replicon plasmid p5ASAL07_294k
Accession NZ_CP090134
Organism Salmonella enterica subsp. enterica serovar Goldcoast strain 5ASAL07

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag LZK29_RS23605 Protein ID WP_000088046.1
Coordinates 245026..246351 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag LZK29_RS23610 Protein ID WP_024136327.1
Coordinates 246356..246649 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZK29_RS23565 (LZK29_23565) 240047..240403 + 357 WP_065311124.1 H-NS family nucleoid-associated regulatory protein -
LZK29_RS23570 (LZK29_23570) 240745..240948 - 204 WP_001194555.1 hypothetical protein -
LZK29_RS23575 (LZK29_23575) 241010..241867 - 858 WP_000784387.1 HNH endonuclease signature motif containing protein -
LZK29_RS23580 (LZK29_23580) 241883..242191 - 309 WP_001224687.1 hypothetical protein -
LZK29_RS23585 (LZK29_23585) 242740..243165 - 426 WP_001043843.1 hypothetical protein -
LZK29_RS23590 (LZK29_23590) 243419..244234 - 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
LZK29_RS23595 (LZK29_23595) 244247..244657 - 411 WP_000985911.1 hypothetical protein -
LZK29_RS23600 (LZK29_23600) 244759..244965 - 207 WP_000134171.1 hypothetical protein -
LZK29_RS23605 (LZK29_23605) 245026..246351 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
LZK29_RS23610 (LZK29_23610) 246356..246649 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
LZK29_RS23615 (LZK29_23615) 247253..247645 - 393 WP_000341066.1 hypothetical protein -
LZK29_RS23620 (LZK29_23620) 248018..248353 + 336 WP_065311125.1 hypothetical protein -
LZK29_RS23625 (LZK29_23625) 248392..249189 - 798 WP_000544828.1 IS21-like element IS21 family helper ATPase IstB -
LZK29_RS23630 (LZK29_23630) 249189..250361 - 1173 WP_000952349.1 IS21-like element IS21 family transposase -
LZK29_RS23635 (LZK29_23635) 250448..251008 - 561 WP_233932670.1 hypothetical protein -
LZK29_RS23640 (LZK29_23640) 251181..251630 - 450 WP_000182314.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid dfrA14 / ARR-3 / qnrS13 / blaCTX-M-55 / blaTEM-1B / blaLAP-2 / aac(3)-IId / floR / sul2 / ant(3'')-Ia / lnu(F) / sul3 / tet(A) / aph(6)-Id / aph(3')-Ia - 1..294023 294023


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T230097 WP_000088046.1 NZ_CP090134:c246351-245026 [Salmonella enterica subsp. enterica serovar Goldcoast]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T230097 NZ_CP124698:324856-325224 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT230097 WP_024136327.1 NZ_CP090134:c246649-246356 [Salmonella enterica subsp. enterica serovar Goldcoast]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT230097 NZ_CP124698:324638-324859 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References