Detailed information of TA system TA230094

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4000191..4000707
• Replicon: chromosome
• Accession: NZ_CP090133
• Organism: Salmonella enterica subsp. enterica serovar Goldcoast strain 5ASAL07

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LZK29_RS19150
• Protein ID: WP_133323120.1
• Coordinates: 4000191..4000475 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V7ISI8
• Locus tag: LZK29_RS19155
• Protein ID: WP_000212724.1
• Coordinates: 4000465..4000707 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZK29_RS19135 (3995403)	3995403..3997055	+	1653	WP_023137597.1	alpha,alpha-phosphotrehalase	-
LZK29_RS19140 (3997464)	3997464..3999602	+	2139	WP_000187818.1	anaerobic ribonucleoside-triphosphate reductase	-
LZK29_RS19145 (3999723)	3999723..4000187	+	465	WP_133323118.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
LZK29_RS19150 (4000191)	4000191..4000475	-	285	WP_133323120.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LZK29_RS19155 (4000465)	4000465..4000707	-	243	WP_000212724.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LZK29_RS19160 (4000785)	4000785..4002698	-	1914	WP_001212140.1	BglG family transcription antiterminator	-
LZK29_RS19165 (4002715)	4002715..4003455	-	741	WP_023229489.1	KDGP aldolase family protein	-
LZK29_RS19170 (4003452)	4003452..4004570	-	1119	WP_133323122.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
LZK29_RS19175 (4004554)	4004554..4005687	-	1134	WP_133323124.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10926.73 Da
• Isoelectric Point: 9.8739

>T230094 WP_133323120.1 NZ_CP090133:c4000475-4000191 [Salmonella enterica subsp. enterica serovar Goldcoast]
MTYELEFDPRALKEWHKLDDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T230094 NZ_CP124696:15670-15975 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT230094 WP_000212724.1 NZ_CP090133:c4000707-4000465 [Salmonella enterica subsp. enterica serovar Goldcoast]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT230094 NZ_CP124696:15450-15668 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A5H5JRI5