Detailed information of TA system TA230090

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3307213..3307833
• Replicon: chromosome
• Accession: NZ_CP090133
• Organism: Salmonella enterica subsp. enterica serovar Goldcoast strain 5ASAL07

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: LZK29_RS15975
• Protein ID: WP_001280991.1
• Coordinates: 3307615..3307833 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: LZK29_RS15970
• Protein ID: WP_000344807.1
• Coordinates: 3307213..3307587 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZK29_RS15960 (3302352)	3302352..3303545	+	1194	WP_126524221.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
LZK29_RS15965 (3303568)	3303568..3306717	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
LZK29_RS15970 (3307213)	3307213..3307587	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
LZK29_RS15975 (3307615)	3307615..3307833	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
LZK29_RS15980 (3308012)	3308012..3308563	+	552	WP_001278793.1	maltose O-acetyltransferase	-
LZK29_RS15985 (3308679)	3308679..3309149	+	471	WP_000136183.1	YlaC family protein	-
LZK29_RS15990 (3309205)	3309205..3309345	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
LZK29_RS15995 (3309351)	3309351..3309611	-	261	WP_115276046.1	type B 50S ribosomal protein L31	-
LZK29_RS16000 (3309836)	3309836..3311386	+	1551	WP_000213138.1	EAL domain-containing protein	-
LZK29_RS16010 (3311617)	3311617..3312006	+	390	WP_000961285.1	MGMT family protein	-
LZK29_RS16015 (3312039)	3312039..3312608	-	570	WP_000779802.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T230090 WP_001280991.1 NZ_CP090133:3307615-3307833 [Salmonella enterica subsp. enterica serovar Goldcoast]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T230090 NZ_CP124693:c4586916-4586383 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGTATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT230090 WP_000344807.1 NZ_CP090133:3307213-3307587 [Salmonella enterica subsp. enterica serovar Goldcoast]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT230090 NZ_CP124693:c4587193-4586927 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0