Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 33466..34000 Replicon plasmid pKP46_2_KPC
Accession NZ_CP090128
Organism Klebsiella pneumoniae strain KP46

Toxin (Protein)


Gene name relE Uniprot ID A0A6P1V8P2
Locus tag LWR79_RS26890 Protein ID WP_000143805.1
Coordinates 33710..34000 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7I6XZR7
Locus tag LWR79_RS26885 Protein ID WP_000104338.1
Coordinates 33466..33720 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LWR79_RS26865 (LWR79_26865) 28821..29270 - 450 WP_045911952.1 hypothetical protein -
LWR79_RS26870 (LWR79_26870) 29520..31349 - 1830 WP_025760371.1 hypothetical protein -
LWR79_RS26875 (LWR79_26875) 31979..32512 + 534 WP_224019189.1 hypothetical protein -
LWR79_RS26880 (LWR79_26880) 32599..33309 + 711 WP_059514180.1 tyrosine-type recombinase/integrase -
LWR79_RS26885 (LWR79_26885) 33466..33720 + 255 WP_000104338.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LWR79_RS26890 (LWR79_26890) 33710..34000 + 291 WP_000143805.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LWR79_RS26895 (LWR79_26895) 34311..34910 - 600 WP_025760201.1 DUF2913 family protein -
LWR79_RS26900 (LWR79_26900) 34930..35652 - 723 WP_025760202.1 NYN domain-containing protein -
LWR79_RS26905 (LWR79_26905) 36755..37630 - 876 WP_094935765.1 incFII family plasmid replication initiator RepA -
LWR79_RS26910 (LWR79_26910) 37631..37815 - 185 Protein_47 protein CopA/IncA -
LWR79_RS26915 (LWR79_26915) 37933..38181 - 249 WP_058670686.1 replication regulatory protein RepA -
LWR79_RS26920 (LWR79_26920) 38334..38888 - 555 WP_059509465.1 phospholipase D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(E) / msr(E) / armA / sul1 / qacE / ant(3'')-Ia / blaKPC-2 - 1..88164 88164


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-47)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11463.41 Da        Isoelectric Point: 10.2689

>T230075 WP_000143805.1 NZ_CP090128:33710-34000 [Klebsiella pneumoniae]
MTFNVEFDERAFKEWNKLEKTIREQFKKKLKKLQQNPYVESARLHGDLAGCFKIKLRASGFRLIYKVIDDEIVIWVVAVG
KREDEKAYETARKRLL

Download         Length: 291 bp

>T230075 NZ_CP124670:c4390577-4389822 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9708.04 Da        Isoelectric Point: 4.4247

>AT230075 WP_000104338.1 NZ_CP090128:33466-33720 [Klebsiella pneumoniae]
MSTIQIRVDDELKKDAYQAFEKLNLSPSDALRLFLRYVAENEKLPFAEVSVMVSEDDEDADILAVVRERLKNPARRIRVN
VDDL

Download         Length: 255 bp

>AT230075 NZ_CP124670:c4391080-4390712 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P1V8P2

Antitoxin

Source ID Structure
AlphaFold DB A0A7I6XZR7

References