230074

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 95343..95823 Replicon plasmid pKP46_1_KPC
Accession NZ_CP090127
Organism Klebsiella pneumoniae strain KP46

Toxin (Protein)


Gene name TsxA Uniprot ID A0A223LMB9
Locus tag LWR79_RS26605 Protein ID WP_058998978.1
Coordinates 95566..95823 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID A0A223LLF6
Locus tag LWR79_RS26600 Protein ID WP_072223385.1
Coordinates 95343..95576 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LWR79_RS26565 (LWR79_26565) 91152..91559 + 408 WP_072223386.1 helix-turn-helix transcriptional regulator -
LWR79_RS26570 (LWR79_26570) 91556..92725 - 1170 WP_058998988.1 MobP1 family relaxase -
LWR79_RS26575 (LWR79_26575) 92729..93316 - 588 WP_161400389.1 hypothetical protein -
LWR79_RS26580 (LWR79_26580) 93620..93904 - 285 WP_058998984.1 putative addiction module antidote protein -
LWR79_RS26585 (LWR79_26585) 93906..94202 - 297 WP_013583078.1 type II toxin-antitoxin system RelE/ParE family toxin -
LWR79_RS26590 (LWR79_26590) 94541..94678 - 138 WP_161400388.1 hypothetical protein -
LWR79_RS26595 (LWR79_26595) 94725..94937 - 213 WP_058998981.1 hypothetical protein -
LWR79_RS26600 (LWR79_26600) 95343..95576 - 234 WP_072223385.1 hypothetical protein Antitoxin
LWR79_RS26605 (LWR79_26605) 95566..95823 - 258 WP_058998978.1 hypothetical protein Toxin
LWR79_RS26610 (LWR79_26610) 95820..96362 - 543 WP_058998977.1 hypothetical protein -
LWR79_RS26615 (LWR79_26615) 96362..96568 - 207 WP_058998975.1 hypothetical protein -
LWR79_RS26620 (LWR79_26620) 96580..96795 - 216 WP_058998973.1 hypothetical protein -
LWR79_RS26625 (LWR79_26625) 96837..97358 - 522 WP_058998971.1 J domain-containing protein -
LWR79_RS26630 (LWR79_26630) 97471..97692 + 222 WP_058998969.1 hypothetical protein -
LWR79_RS26635 (LWR79_26635) 98433..99461 + 1029 WP_080398146.1 replication initiator protein A -
LWR79_RS26640 (LWR79_26640) 99466..99918 + 453 WP_058998967.1 hypothetical protein -
LWR79_RS26645 (LWR79_26645) 99893..100426 + 534 WP_227818513.1 phospholipase D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaKPC-2 - 1..103807 103807


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(7-36)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9777.10 Da        Isoelectric Point: 9.3899

>T230074 WP_058998978.1 NZ_CP090127:c95823-95566 [Klebsiella pneumoniae]
MKKSKGDAQYYLEKEGDIYHLVKRVKTFSKKLTQGKTKATTKTVSDFSFTKNNFEDIDFNANGLREKDKSIIVQMVEEIE
GLHAD

Download         Length: 258 bp

>T230074 NZ_CP124670:3468727-3469305 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8887.37 Da        Isoelectric Point: 8.5202

>AT230074 WP_072223385.1 NZ_CP090127:c95576-95343 [Klebsiella pneumoniae]
MLINTPENIKILRKKIGLTQKECAEMFGMTARSWRRKEEPQTTASNTTLSPIEFNYLLLLAGEHPDYVLCKREALHP

Download         Length: 234 bp

>AT230074 NZ_CP124670:3468084-3468638 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A223LMB9

Antitoxin

Source ID Structure
AlphaFold DB A0A223LLF6

References