Detailed information of TA system TA230066

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2731294..2732882
• Replicon: chromosome
• Accession: NZ_CP090126
• Organism: Klebsiella pneumoniae strain KP46

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LWR79_RS13345
• Protein ID: WP_004179815.1
• Coordinates: 2731294..2732616 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LWR79_RS13350
• Protein ID: WP_004176198.1
• Coordinates: 2732616..2732882 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LWR79_RS13330 (2726350)	2726350..2728851	+	2502	WP_020323802.1	fimbria/pilus outer membrane usher protein	-
LWR79_RS13335 (2728839)	2728839..2729843	+	1005	WP_004179822.1	fimbrial protein	-
LWR79_RS13340 (2729985)	2729985..2731277	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
LWR79_RS13345 (2731294)	2731294..2732616	-	1323	WP_004179815.1	type II toxin-antitoxin system HipA family toxin	Toxin
LWR79_RS13350 (2732616)	2732616..2732882	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LWR79_RS13355 (2733148)	2733148..2733474	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
LWR79_RS13360 (2733471)	2733471..2733971	-	501	WP_004179811.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LWR79_RS13365 (2733949)	2733949..2735328	-	1380	WP_004179808.1	nucleobase:cation symporter-2 family protein	-
LWR79_RS13370 (2735674)	2735674..2736828	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
LWR79_RS13375 (2736809)	2736809..2737732	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T230066 WP_004179815.1 NZ_CP090126:c2732616-2731294 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T230066 NZ_CP124669:c152713-152432 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT230066 WP_004176198.1 NZ_CP090126:c2732882-2732616 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT230066 NZ_CP124669:c152937-152710 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA