230057

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 840410..841067 Replicon chromosome
Accession NZ_CP090126
Organism Klebsiella pneumoniae strain KP46

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LWR79_RS04160 Protein ID WP_002916310.1
Coordinates 840657..841067 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LWR79_RS04155 Protein ID WP_002916312.1
Coordinates 840410..840676 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LWR79_RS04130 (835566) 835566..836999 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
LWR79_RS04135 (837118) 837118..837846 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LWR79_RS04140 (837896) 837896..838207 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LWR79_RS04145 (838371) 838371..839030 + 660 WP_002916317.1 hemolysin III family protein -
LWR79_RS04150 (839181) 839181..840164 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
LWR79_RS04155 (840410) 840410..840676 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LWR79_RS04160 (840657) 840657..841067 + 411 WP_002916310.1 protein YgfX Toxin
LWR79_RS04165 (841074) 841074..841595 - 522 WP_004144730.1 flavodoxin FldB -
LWR79_RS04170 (841696) 841696..842592 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LWR79_RS04175 (842615) 842615..843328 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LWR79_RS04180 (843334) 843334..845067 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T230057 WP_002916310.1 NZ_CP090126:840657-841067 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T230057 NZ_CP124667:c4982445-4982098 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCACTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGTGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT230057 WP_002916312.1 NZ_CP090126:840410-840676 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT230057 NZ_CP124667:c4982706-4982455 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTATTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References