230050

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1345325..1346241 Replicon chromosome
Accession NZ_CP090125
Organism Bacillus subtilis strain Bs96

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag LXE94_RS07085 Protein ID WP_003244695.1
Coordinates 1345495..1346241 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID -
Locus tag LXE94_RS07080 Protein ID WP_257986573.1
Coordinates 1345325..1345495 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXE94_RS07040 (1340449) 1340449..1342176 + 1728 WP_250622002.1 terminase -
LXE94_RS07045 (1342188) 1342188..1342517 + 330 WP_032725528.1 XkdW family protein -
LXE94_RS07050 (1342514) 1342514..1342678 + 165 WP_087960875.1 XkdX family protein -
LXE94_RS07055 (1342722) 1342722..1343561 + 840 WP_041351214.1 phage-like element PBSX protein XepA -
LXE94_RS07060 (1343614) 1343614..1343883 + 270 WP_041351215.1 hemolysin XhlA family protein -
LXE94_RS07065 (1343896) 1343896..1344159 + 264 WP_014479566.1 phage holin -
LXE94_RS07070 (1344172) 1344172..1345065 + 894 WP_014479567.1 N-acetylmuramoyl-L-alanine amidase -
LXE94_RS07075 (1345102) 1345102..1345239 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
LXE94_RS07080 (1345325) 1345325..1345495 - 171 WP_257986573.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
LXE94_RS07085 (1345495) 1345495..1346241 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
LXE94_RS07090 (1346351) 1346351..1347352 - 1002 WP_014479569.1 inorganic phosphate transporter -
LXE94_RS07095 (1347365) 1347365..1347982 - 618 WP_003218470.1 DUF47 domain-containing protein -
LXE94_RS07100 (1348258) 1348258..1349574 - 1317 WP_257986574.1 serine/threonine exchanger -
LXE94_RS07105 (1349963) 1349963..1350913 + 951 WP_121591714.1 ring-cleaving dioxygenase -
LXE94_RS07110 (1351022) 1351022..1351123 + 102 Protein_1337 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T230050 WP_003244695.1 NZ_CP090125:c1346241-1345495 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

>T230050 NZ_CP124666:c4559558-4558803 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATGTCCGACCGCTCCAGGGGCGGCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGTTGGGGG
TCGCGGTTTGGCCGTCGTCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGTGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6668.79 Da        Isoelectric Point: 11.0859

>AT230050 WP_257986573.1 NZ_CP090125:c1345495-1345325 [Bacillus subtilis]
MERAFQKRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp

>AT230050 NZ_CP124666:c4560061-4559693 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCTGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGGGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTGGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure

References