Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 423963..424627 Replicon plasmid pRL1
Accession NZ_CP090103
Organism Rhizobium leguminosarum strain Tp73_4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LZK79_RS34620 Protein ID WP_130794222.1
Coordinates 423963..424376 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LZK79_RS34625 Protein ID WP_130784586.1
Coordinates 424373..424627 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZK79_RS34605 (LZK79_34615) 419575..420588 - 1014 WP_011648922.1 ABC transporter permease -
LZK79_RS34610 (LZK79_34620) 420658..422328 - 1671 WP_028742529.1 ABC transporter substrate-binding protein -
LZK79_RS34615 (LZK79_34625) 422523..423533 - 1011 WP_130784584.1 GlxA family transcriptional regulator -
LZK79_RS34620 (LZK79_34630) 423963..424376 - 414 WP_130794222.1 type II toxin-antitoxin system VapC family toxin Toxin
LZK79_RS34625 (LZK79_34635) 424373..424627 - 255 WP_130784586.1 plasmid stabilization protein Antitoxin
LZK79_RS34630 (LZK79_34640) 424854..425822 - 969 WP_130784587.1 cyclase family protein -
LZK79_RS34635 (LZK79_34645) 425868..427241 - 1374 WP_130784588.1 amidase -
LZK79_RS34640 (LZK79_34650) 427261..428469 - 1209 WP_130784589.1 extracellular solute-binding protein -
LZK79_RS34645 (LZK79_34655) 428466..429506 - 1041 WP_011648930.1 GTP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..825442 825442


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14721.13 Da        Isoelectric Point: 5.7238

>T230047 WP_130794222.1 NZ_CP090103:c424376-423963 [Rhizobium leguminosarum]
MILLDTNVISEPCKPIPDGAVVAWLDAQAIETLFVSAITIAELRFAIAAMPAGKRQTILRDRLEEEVLPHFAERILPFDL
AASQFYSELMARARVSGKGSARGHIAATAVANGLAVATRDTGPFEAVGLKVINPWLP

Download         Length: 414 bp

>T230047 NZ_CP124666:1642431-1643300 [Pseudomonas aeruginosa]
ATGAACATGGCGCAGACCCACACCCCCGTCCCGAACCTGCAACAGCGCTTTCCCGAGCGGCTGGTGCAACTGGCCGACGG
CGCCCAGCTGGCCATCCGCGAATGCGGCCAGGGCCCGGTGGTGGTGCTGTTGCACGGCATCGGTTCGGGCTCGGCGTCCT
GGCTGCATTGCGCCCAGCGCCTGGCCGCCGGCAATCGGGTGATCGCCTGGGACGCGCCGGGTTACGGCCTGTCCACGCCG
CTGCCGCCGGCCCGGCCCAAGGCCTGCGACTACGCCGCGTGCCTGGAGCTGCTGCTGGATGCGCTGGGCGTGGAGAGCTG
CCTGCTGGTGGGCCACTCCCTCGGCGCGCTGATGGCCACGGCCTACGCCGCCGGCATCGGCGCGGCGCGGGTGCGCCGCC
TGGTGCTGCTCAGCCCGGCGCGCGGCTACGGCGCCGCCGAGCTGCGCGACAGCGGCGCCCAGGTGCGCCGCCAGCGCCTG
GAGAACCTGGAGCGCTTCGGTATCGACGGCATGGCCAGCGAGCGCACCGCGCGCCTGCTCGGCCGCAACCCCAGCGAGGA
GGCCCTGGCCTGGGTGCGCTGGAACATGGCGCGGCTCAACCCCGAGGGCTACCGCCAGGCCGTCGAGCTGCTCTGCGGCG
ACGACCTGCTGGGCAACGGGCAGCCTGCCGCTCCTTGCGAGGTGCATTGCGGCGAGGACGACGGCATCACCACGCCCGAG
AGTTGCGGCGCCATCGCCCGCCAGCTCGGCGCGTCGTTCTCGTCGATTCCCGGGGCCGGCCACGCCAGCCCGATCGAACA
ACCCGAAGTGGTCGCAGGACGCATCGGCCACGCGCAACGCCTCTCTCTTGAAGGAACCGCCAATGGATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9286.43 Da        Isoelectric Point: 6.7270

>AT230047 WP_130784586.1 NZ_CP090103:c424627-424373 [Rhizobium leguminosarum]
MPAVTIRNLSDETHRALRVRAAHHGRSTEAEIRDIIEAAVRPSERVKLGSLLATIGRDAELSNSDVEALQQNRNKAPAEP
MTFE

Download         Length: 255 bp

>AT230047 NZ_CP124666:1643293-1644126 [Pseudomonas aeruginosa]
ATGGATAAGTCAGACGATTCGCAAGACAAGTACATCGTGCCTGGCCTCGAACGCGGCCTGCTGCTGCTCTGCGAGTTCAG
CCGGAAGGACCGTACCCTGACGGCGCCGGAGTTGGCGCGGCGCCTGAAGCTGCCGCGCTCGACCATCTTCCGCCTGCTGA
CCACCCTGGAGGCCATGGGCTTCGTCACCCGCAACGGCAACGAGTACCGCCTGGGCATGGCGGTGTTGCGCCTGGGCTTC
GAGTACCTGGCCTCGCTGGAGCTGACCGAACTCGGCCAGCCGCTGCTGAACCGCCTGTGCGACGAGATCCGCTACCCCTG
CAACCTGGTGGTGCGCGACGGCCGTTCGATCGTCTACGTGGCCAAGGTTTCGCCGTCCACCCCGCTGAGCAGCTCGGTGA
ACGTCGGGACCCGGTTGCCGGCCCACGCCACGGTGCTCGGCCGCATCCTGCTGCAGGACCTGAGCCTGGGCGAGCTGCGC
GAGCTGTACCCGGAGGAGCAGCTGGAGCAGTTCTCGCCGAACACCCCGCGCAGCGTGCTGGAACTCTTCGACATGGTCCA
GGGCGACCGCCAGCGTGGCTTCGTCCAGGGCGAGGGGTTCTTCGAGGCGAGCATCTCCACCGTCGCGGCGCCGGTACGTG
ATCACAGCGGTCGCGTCATCGCGGCGATGGGGGCGACCATCGCCGCCGGGCATATCGACCCGGAACGCATCGAGGGACTG
GTCAGCCGGGTGCGCAGCAGCGCCGACGAGCTGTCGTACCTGCTCGACTACCGCGCCGACGGCCAGGACAACGTCACCCC
GATCTTCCGGAGTCGCCCGCATGAAACCGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References