Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 141007..141542 Replicon plasmid pRL1
Accession NZ_CP090103
Organism Rhizobium leguminosarum strain Tp73_4

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LZK79_RS33330 Protein ID WP_233939198.1
Coordinates 141267..141542 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8G2J5T9
Locus tag LZK79_RS33325 Protein ID WP_028742964.1
Coordinates 141007..141267 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZK79_RS33305 (LZK79_33315) 136836..137849 - 1014 WP_011649425.1 ABC transporter substrate-binding protein -
LZK79_RS33310 (LZK79_33320) 138194..139204 - 1011 WP_028742961.1 helix-turn-helix domain-containing protein -
LZK79_RS33315 (LZK79_33325) 139201..139779 - 579 WP_011649427.1 isochorismatase family protein -
LZK79_RS33320 (LZK79_33330) 139973..140701 - 729 WP_028742963.1 FadR/GntR family transcriptional regulator -
LZK79_RS33325 (LZK79_33335) 141007..141267 + 261 WP_028742964.1 ribbon-helix-helix domain-containing protein Antitoxin
LZK79_RS33330 (LZK79_33340) 141267..141542 + 276 WP_233939198.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZK79_RS33335 (LZK79_33345) 141549..142556 - 1008 WP_028742966.1 LacI family DNA-binding transcriptional regulator -
LZK79_RS33340 (LZK79_33350) 142764..144086 + 1323 WP_233939146.1 alpha-L-fucosidase -
LZK79_RS33345 (LZK79_33355) 144137..145360 + 1224 WP_130794070.1 sugar ABC transporter substrate-binding protein -
LZK79_RS33350 (LZK79_33360) 145443..146417 + 975 WP_233939147.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..825442 825442


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10840.50 Da        Isoelectric Point: 9.9288

>T230045 WP_233939198.1 NZ_CP090103:141267-141542 [Rhizobium leguminosarum]
MELKWTSKAVSDVARLYDFLAPVDRLAAARTVQALTKAPARLLDQPRLGERLEEFDPREVRRILIGRYELRYEIQQSTIY
VLRLWHTREDR

Download         Length: 276 bp

>T230045 NZ_CP124665:c5442053-5441775 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCTGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9630.82 Da        Isoelectric Point: 4.6005

>AT230045 WP_028742964.1 NZ_CP090103:141007-141267 [Rhizobium leguminosarum]
METKVLTAHVPLSLAQKVDQLASRLERSRGWIVKQALTAWIDQEEERRRLTLEALADVDDGNVVDHQSVQAWADSLDGDA
PISLPR

Download         Length: 261 bp

>AT230045 NZ_CP124665:c5441763-5441458 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References