Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 2632751..2633349 Replicon chromosome
Accession NZ_CP090098
Organism Rhizobium leguminosarum strain Tp73_4

Toxin (Protein)


Gene name relE Uniprot ID A0A8G2MT35
Locus tag LZK79_RS13010 Protein ID WP_027667450.1
Coordinates 2632751..2633044 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q1MGB2
Locus tag LZK79_RS13015 Protein ID WP_011652079.1
Coordinates 2633041..2633349 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZK79_RS12990 (LZK79_12995) 2629200..2630333 + 1134 WP_028741306.1 esterase-like activity of phytase family protein -
LZK79_RS12995 (LZK79_13000) 2630450..2631667 + 1218 WP_003539854.1 AI-2E family transporter -
LZK79_RS13000 (LZK79_13005) 2631687..2632145 - 459 WP_011652077.1 GNAT family N-acetyltransferase -
LZK79_RS13005 (LZK79_13010) 2632275..2632694 + 420 WP_011652078.1 hypothetical protein -
LZK79_RS13010 (LZK79_13015) 2632751..2633044 - 294 WP_027667450.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
LZK79_RS13015 (LZK79_13020) 2633041..2633349 - 309 WP_011652079.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LZK79_RS13020 (LZK79_13025) 2633485..2634627 - 1143 WP_130787060.1 DUF2336 domain-containing protein -
LZK79_RS13025 (LZK79_13030) 2634729..2635346 - 618 WP_130792933.1 flavin reductase family protein -
LZK79_RS13030 (LZK79_13035) 2635346..2635930 - 585 WP_233938271.1 nitroreductase -
LZK79_RS13035 (LZK79_13040) 2636044..2637144 + 1101 WP_130787063.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-58)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11116.82 Da        Isoelectric Point: 8.5341

>T230042 WP_027667450.1 NZ_CP090098:c2633044-2632751 [Rhizobium leguminosarum]
VRLVWARYALSDRENIFTYIEIENPRAAVHVDQKIVLAVRRLVEFPESGRPGRIAGTRELVIPSTPYIAAYVVHEDRIRI
LRVLHGAQIWPDAISTD

Download         Length: 294 bp

>T230042 NZ_CP124665:1911614-1912201 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGACGTTGCCGCTCGCTGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGTGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11285.67 Da        Isoelectric Point: 4.7051

>AT230042 WP_011652079.1 NZ_CP090098:c2633349-2633041 [Rhizobium leguminosarum]
MASNALVQTRIDAAVKDRATAVLENMGLTVSDVVRILLTRTANEGALPLELISNSDAYDAWFRGKVLEALHDTRPDVDDT
EVETGFEKRREAALRKSQVDRS

Download         Length: 309 bp

>AT230042 NZ_CP124665:1912268-1913122 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTGGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTGGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAGATGGAGCAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGTTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGCGAGACGGTGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGTGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGCTCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGAGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGGCAGCGCCGCCTGGAGCAGGCCAGAGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGGGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCGTCCTTGACGACATACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q1MGB2

References