Detailed information of TA system TA230039

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 3015080..3015672
• Replicon: chromosome
• Accession: NZ_CP090095
• Organism: Neorhizobium galegae strain 7g

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LZK81_RS14970
• Protein ID: WP_233953774.1
• Coordinates: 3015080..3015268 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LZK81_RS14975
• Protein ID: WP_233953775.1
• Coordinates: 3015271..3015672 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZK81_RS14950 (LZK81_14950)	3011494..3013710	+	2217	WP_233953772.1	copper-translocating P-type ATPase	-
LZK81_RS14955 (LZK81_14955)	3013707..3013892	+	186	WP_046603734.1	DUF2933 domain-containing protein	-
LZK81_RS14960 (LZK81_14960)	3013889..3014194	+	306	WP_233953773.1	hypothetical protein	-
LZK81_RS14965 (LZK81_14965)	3014223..3014966	-	744	WP_052758995.1	hypothetical protein	-
LZK81_RS14970 (LZK81_14970)	3015080..3015268	+	189	WP_233953774.1	type II toxin-antitoxin system HicA family toxin	Toxin
LZK81_RS14975 (LZK81_14975)	3015271..3015672	+	402	WP_233953775.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LZK81_RS14980 (LZK81_14980)	3015677..3016426	-	750	WP_233953776.1	metallophosphoesterase family protein	-
LZK81_RS14985 (LZK81_14985)	3016426..3016782	-	357	WP_233953777.1	hydroxyisourate hydrolase	-
LZK81_RS14990 (LZK81_14990)	3016779..3017279	-	501	WP_046609164.1	ureidoglycolate lyase	-
LZK81_RS14995 (LZK81_14995)	3017309..3017671	-	363	WP_046625260.1	DUF86 domain-containing protein	-
LZK81_RS15000 (LZK81_15000)	3017668..3017958	-	291	WP_046603727.1	nucleotidyltransferase family protein	-
LZK81_RS15005 (LZK81_15005)	3018027..3018524	-	498	WP_233953778.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LZK81_RS15010 (LZK81_15010)	3018521..3019447	-	927	WP_046625258.1	allantoinase PuuE	-
LZK81_RS15015 (LZK81_15015)	3019519..3019821	-	303	WP_233953779.1	AzlD domain-containing protein	-
LZK81_RS15020 (LZK81_15020)	3019818..3020486	-	669	WP_233956574.1	AzlC family ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7069.38 Da
• Isoelectric Point: 12.1834

>T230039 WP_233953774.1 NZ_CP090095:3015080-3015268 [Neorhizobium galegae]
MKSAEVTALLRRNGWMEVARKGSHVQFKHPQKPGRVTMPHPKRDIPLGTLRSIEKQAGLKLR

Nucleotide

• Length: 189 bp

>T230039 NZ_CP124664:c5523013-5522735 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14315.04 Da
• Isoelectric Point: 4.3635

>AT230039 WP_233953775.1 NZ_CP090095:3015271-3015672 [Neorhizobium galegae]
VSNYIGLIHKNAESDYGVSFPDFPGVVTAGATLDEARHMAEEALAFHVEGMVEDGETIPEPSSLESVMTNPDNLDGVAIL
VTLKTQVAKAVRINITLPEDVLERIDRFAADHGLSRSGFLARAASHEIERITG

Nucleotide

• Length: 402 bp

>AT230039 NZ_CP124664:c5522723-5522418 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG