Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 397962..398497 | Replicon | plasmid pRLgr12_3 |
| Accession | NZ_CP090094 | ||
| Organism | Rhizobium leguminosarum strain Gr 12/7 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | LZK78_RS36310 | Protein ID | WP_128409564.1 |
| Coordinates | 398207..398497 (+) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A4R0A0Z6 |
| Locus tag | LZK78_RS36305 | Protein ID | WP_072642369.1 |
| Coordinates | 397962..398210 (+) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZK78_RS36290 (LZK78_36300) | 393548..395257 | + | 1710 | WP_128403485.1 | ABC transporter ATP-binding protein | - |
| LZK78_RS36295 (LZK78_36305) | 395277..396791 | + | 1515 | WP_128403486.1 | ABC transporter substrate-binding protein | - |
| LZK78_RS36300 (LZK78_36310) | 396876..397751 | - | 876 | WP_105010207.1 | glutathione-dependent disulfide-bond oxidoreductase | - |
| LZK78_RS36305 (LZK78_36315) | 397962..398210 | + | 249 | WP_072642369.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| LZK78_RS36310 (LZK78_36320) | 398207..398497 | + | 291 | WP_128409564.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LZK78_RS36315 (LZK78_36325) | 398509..399411 | - | 903 | WP_128403487.1 | NAD(P)-dependent oxidoreductase | - |
| LZK78_RS36320 (LZK78_36330) | 399572..400039 | + | 468 | WP_233943948.1 | universal stress protein | - |
| LZK78_RS36325 (LZK78_36335) | 400157..401071 | + | 915 | WP_128403489.1 | J domain-containing protein | - |
| LZK78_RS36330 (LZK78_36340) | 401074..401397 | + | 324 | WP_026236977.1 | chaperone modulator CbpM | - |
| LZK78_RS36335 (LZK78_36345) | 401412..402341 | - | 930 | WP_128403490.1 | phosphatidate cytidylyltransferase | - |
| LZK78_RS36340 (LZK78_36350) | 402338..402958 | - | 621 | WP_233943951.1 | lysophospholipid acyltransferase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | gmd | 1..643794 | 643794 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11151.72 Da Isoelectric Point: 9.5233
>T230029 WP_128409564.1 NZ_CP090094:398207-398497 [Rhizobium leguminosarum]
MTGIIFSPAAQTDIDKIWDYTATSWNVDQAERYIQDIRDACHELAEGRRMSRPSDIRKGYRKVSVGSHFLYFKSNDAGQI
IIVRILHRRMDVAKHL
MTGIIFSPAAQTDIDKIWDYTATSWNVDQAERYIQDIRDACHELAEGRRMSRPSDIRKGYRKVSVGSHFLYFKSNDAGQI
IIVRILHRRMDVAKHL
Download Length: 291 bp
>T230029 NZ_CP124663:3581517-3582095 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTTTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTTCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAAGCGGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCATCTGGACAC
GCCGCTGCGCGATCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGACCGCCGAAGCCCTGGCAGTGAAAGCGC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGTTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTTTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTTCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAAGCGGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCATCTGGACAC
GCCGCTGCGCGATCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGACCGCCGAAGCCCTGGCAGTGAAAGCGC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGTTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG
Antitoxin
Download Length: 83 a.a. Molecular weight: 8956.96 Da Isoelectric Point: 5.0893
>AT230029 WP_072642369.1 NZ_CP090094:397962-398210 [Rhizobium leguminosarum]
MARNTSISLGEHFTSFIDTQVQAGRYGSATDVVRAGLRLLEEHEAKVKALQDALIEGEESGPATPFDFDAFNARKRAAFE
AK
MARNTSISLGEHFTSFIDTQVQAGRYGSATDVVRAGLRLLEEHEAKVKALQDALIEGEESGPATPFDFDAFNARKRAAFE
AK
Download Length: 249 bp
>AT230029 NZ_CP124663:3580875-3581429 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAAGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAAGCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCCCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAAGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAAGCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCCCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|