Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 145595..146130 Replicon plasmid pRL1
Accession NZ_CP090093
Organism Rhizobium leguminosarum strain Gr 12/7

Toxin (Protein)


Gene name relE Uniprot ID A0A444HTS0
Locus tag LZK78_RS29545 Protein ID WP_029733073.1
Coordinates 145855..146130 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3S0SSF2
Locus tag LZK78_RS29540 Protein ID WP_047618843.1
Coordinates 145595..145855 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZK78_RS29520 (LZK78_29530) 141427..142440 - 1014 WP_128401453.1 ABC transporter substrate-binding protein -
LZK78_RS29525 (LZK78_29535) 142796..143806 - 1011 WP_128401452.1 helix-turn-helix domain-containing protein -
LZK78_RS29530 (LZK78_29540) 143803..144369 - 567 WP_128401451.1 isochorismatase family protein -
LZK78_RS29535 (LZK78_29545) 144575..145303 - 729 WP_128401471.1 FadR/GntR family transcriptional regulator -
LZK78_RS29540 (LZK78_29550) 145595..145855 + 261 WP_047618843.1 ribbon-helix-helix domain-containing protein Antitoxin
LZK78_RS29545 (LZK78_29555) 145855..146130 + 276 WP_029733073.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZK78_RS29550 (LZK78_29560) 146137..147144 - 1008 WP_128401450.1 LacI family DNA-binding transcriptional regulator -
LZK78_RS29555 (LZK78_29565) 147352..148674 + 1323 WP_128401449.1 alpha-L-fucosidase -
LZK78_RS29560 (LZK78_29570) 148725..149944 + 1220 Protein_146 sugar ABC transporter substrate-binding protein -
LZK78_RS29565 (LZK78_29575) 150012..150938 + 927 WP_128401447.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..1182792 1182792


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10858.44 Da        Isoelectric Point: 9.9696

>T230025 WP_029733073.1 NZ_CP090093:145855-146130 [Rhizobium leguminosarum]
MEVKWTSKAVSDVTRLYDFLSPVDRRAAARTVQALTAAPARLLEQPRLGERLEEFDPREVRRILVGRYELRYEIQQSTIY
VLRLWHTREDR

Download         Length: 276 bp

>T230025 NZ_CP124662:c6058117-6057839 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9684.91 Da        Isoelectric Point: 4.6135

>AT230025 WP_047618843.1 NZ_CP090093:145595-145855 [Rhizobium leguminosarum]
METKVLTAHVPLPLAQKVDQLASRLERSRGWIVKQALTAWIDQEEERRRLTLEALADVDSGNVVDHQAVQAWADSLDSDE
PISLPR

Download         Length: 261 bp

>AT230025 NZ_CP124662:c6057827-6057522 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAATGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A444HTS0

Antitoxin

Source ID Structure
AlphaFold DB A0A3S0SSF2

References